ALS Model Glia Can Mediate Toxicity to Motor Neurons Derived from Human Embryonic Stem Cells

被引：18
|
作者：
Hedlund, Eva [1 ]
Isacson, Ole [2 ,3 ,4 ]
机构：
[1] Karolinska Inst, Ludwig Inst Canc Res, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden
[2] Harvard Univ, Dept Neurol, Sch Med, Belmont, MA 02478 USA
[3] Harvard Univ, Dept Psychiat, Sch Med, Belmont, MA 02478 USA
[4] Harvard Univ, Ctr Neuroregenerat Res, Sch Med, McLean Hosp, Belmont, MA 02478 USA
来源：
CELL STEM CELL | 2008年 / 3卷 / 06期
关键词：
D O I：
10.1016/j.stem.2008.11.004
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this issue of Cell Stem Cell, Di Giorgio et al. (2008) and Marchetto et al. (2008) culture motor neurons derived from human embryonic stem cells with astrocytes expressing mutant SOD1. In these human ALS models, motor neurons are selectively destroyed by mutant astrocyte-secreted factors, and potential neuroprotective pathways are revealed.
引用
收藏
页码：575 / 576
页数：2
相关论文
共 50 条
  • [21] HUMAN STEM CELL DERIVED MOTOR NEURONS TO MODEL MULTIFOCAL MOTOR NEUROPATHY
    Harschnitz, O.
    Jansen, M.
    Vlam, L.
    Kling, S.
    Jongbloed, B. A.
    Pasterkamp, R. J.
    van den Berg, L. H.
    van der Pol, W. L.
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2014, 19 (03) : 264 - 264
  • [22] Specification of functional neurons and glia from human pluripotent stem cells
    Yuan Jiang
    Mei-Jiang Zhang
    Bao-Yang Hu
    Protein & Cell, 2012, 3 (11) : 818 - 825
  • [23] Specification of functional neurons and glia from human pluripotent stem cells
    Jiang, Yuan
    Zhang, Mei-Jiang
    Hu, Bao-Yang
    PROTEIN & CELL, 2012, 3 (11) : 818 - 825
  • [24] An In Vitro Human Segmentation Clock Model Derived from Embryonic Stem Cells
    Chu, Li-Fang
    Mamott, Daniel
    Ni, Zijian
    Bacher, Rhonda
    Liu, Cathy
    Swanson, Scott
    Kendziorski, Christina
    Stewart, Ron
    Thomson, James A.
    CELL REPORTS, 2019, 28 (09): : 2247 - +
  • [25] Endothelial cells derived from human embryonic stem cells
    Levenberg, S
    Golub, JS
    Amit, M
    Itskovitz-Eldor, J
    Langer, R
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (07) : 4391 - 4396
  • [26] Human Motor Neurons Generated from Neural Stem Cells Delay Clinical Onset and Prolong Life in ALS Mouse Model
    Lee, Hong J.
    Kim, Kwang S.
    Ahn, Jin
    Bae, Hye M.
    Lim, Inja
    Kim, Seung U.
    PLOS ONE, 2014, 9 (05):
  • [27] Human embryonic stem cells derived from blastomeres
    Roitberg, Ben
    SURGICAL NEUROLOGY, 2007, 67 (02): : 112 - 112
  • [28] Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
    Alshawaf, Abdullah Jawad
    Viventi, Serena
    Qiu, Wanzhi
    D'Abaco, Giovanna
    Nayagam, Bryony
    Erlichster, Michael
    Chana, Gursharan
    Everall, Ian
    Ivanusic, Jason
    Skafidas, Efstratios
    Dottori, Mirella
    SCIENTIFIC REPORTS, 2018, 8
  • [29] Immature Responses to GABA in Fragile X Neurons Derived from Human Embryonic Stem Cells
    Telias, Michael
    Segal, Menahem
    Ben-Yosef, Dalit
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2016, 10
  • [30] Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
    Abdullah Jawad Alshawaf
    Serena Viventi
    Wanzhi Qiu
    Giovanna D’Abaco
    Bryony Nayagam
    Michael Erlichster
    Gursharan Chana
    Ian Everall
    Jason Ivanusic
    Efstratios Skafidas
    Mirella Dottori
    Scientific Reports, 8
12345