ALS Model Glia Can Mediate Toxicity to Motor Neurons Derived from Human Embryonic Stem Cells

被引：18
|
作者：
Hedlund, Eva [1 ]
Isacson, Ole [2 ,3 ,4 ]
机构：
[1] Karolinska Inst, Ludwig Inst Canc Res, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden
[2] Harvard Univ, Dept Neurol, Sch Med, Belmont, MA 02478 USA
[3] Harvard Univ, Dept Psychiat, Sch Med, Belmont, MA 02478 USA
[4] Harvard Univ, Ctr Neuroregenerat Res, Sch Med, McLean Hosp, Belmont, MA 02478 USA
来源：
CELL STEM CELL | 2008年 / 3卷 / 06期
关键词：
D O I：
10.1016/j.stem.2008.11.004
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this issue of Cell Stem Cell, Di Giorgio et al. (2008) and Marchetto et al. (2008) culture motor neurons derived from human embryonic stem cells with astrocytes expressing mutant SOD1. In these human ALS models, motor neurons are selectively destroyed by mutant astrocyte-secreted factors, and potential neuroprotective pathways are revealed.
引用
收藏
页码：575 / 576
页数：2
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