Dengue viruses cluster antigenically but not as discrete serotypes

被引:173
作者
Katzelnick, Leah C. [1 ,2 ,3 ,4 ]
Fonville, Judith M. [1 ,2 ,5 ]
Gromowski, Gregory D. [3 ]
Arriaga, Jose Bustos [3 ]
Green, Angela [4 ]
James, Sarah L. [1 ,2 ]
Lau, Louis [4 ]
Montoya, Magelda [4 ]
Wang, Chunling [4 ]
VanBlargan, Laura A. [3 ]
Russell, Colin A. [6 ]
Thu, Hlaing Myat [7 ]
Pierson, Theodore C. [3 ]
Buchy, Philippe [8 ]
Aaskov, John G. [9 ,10 ]
Munoz-Jordan, Jorge L. [11 ]
Vasilakis, Nikos [12 ,13 ,14 ,15 ]
Gibbons, Robert V. [16 ]
Tesh, Robert B. [12 ,13 ,14 ,15 ]
Osterhaus, Albert D. M. E. [5 ]
Fouchier, Ron A. M. [5 ]
Durbin, Anna [17 ]
Simmons, Cameron P. [18 ,19 ,20 ]
Holmes, Edward C. [21 ,22 ]
Harris, Eva [4 ]
Whitehead, Stephen S. [3 ]
Smith, Derek J. [1 ,2 ,5 ]
机构
[1] Univ Cambridge, Dept Zool, Ctr Pathogen Evolut, Cambridge CB2 3EJ, England
[2] World Hlth Org WHO Collaborating Ctr Modeling Evo, Cambridge CB2 3EJ, England
[3] NIAID, NIH, Bethesda, MD 20892 USA
[4] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA
[5] Erasmus MC, Dept Virosci, NL-3015 GE Rotterdam, Netherlands
[6] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England
[7] Dept Med Res, Yangon, Myanmar
[8] Reseau Int Inst Pasteur, Inst Pasteur Cambodia, Phnom Penh 12201, Cambodia
[9] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia
[10] Australian Army Malaria Inst, Brisbane, Qld 4051, Australia
[11] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, San Juan, PR 00971 USA
[12] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA
[13] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA
[14] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 USA
[15] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA
[16] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand
[17] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Ctr Immunizat Res, Baltimore, MD 21205 USA
[18] Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam
[19] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford OX3 7LJ, England
[20] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia
[21] Univ Sydney, Sch Biol Sci, Charles Perkins Ctr, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia
[22] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia
基金
英国医学研究理事会;
关键词
NEUTRALIZING ANTIBODY-LEVELS; HEMORRHAGIC-FEVER; INFECTION; VACCINE; IDENTIFICATION; TRANSMISSION; PROTECTION; EMERGENCE; EVOLUTION; RESPONSES;
D O I
10.1126/science.aac5017
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution. We characterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.
引用
收藏
页码:1338 / 1343
页数:6
相关论文
共 41 条
[1]   Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok [J].
Adams, B. ;
Holmes, E. C. ;
Zhang, C. ;
Mammen, M. P., Jr. ;
Nimmannitya, S. ;
Kalayanarooj, S. ;
Boots, M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14234-14239
[2]   The global distribution and burden of dengue [J].
Bhatt, Samir ;
Gething, Peter W. ;
Brady, Oliver J. ;
Messina, Jane P. ;
Farlow, Andrew W. ;
Moyes, Catherine L. ;
Drake, John M. ;
Brownstein, John S. ;
Hoen, Anne G. ;
Sankoh, Osman ;
Myers, Monica F. ;
George, Dylan B. ;
Jaenisch, Thomas ;
Wint, G. R. William ;
Simmons, Cameron P. ;
Scott, Thomas W. ;
Farrar, Jeremy J. ;
Hay, Simon I. .
NATURE, 2013, 496 (7446) :504-507
[3]   Dengue Virus Neutralizing Antibody Levels Associated with Protection from Infection in Thai Cluster Studies [J].
Buddhari, Darunee ;
Aldstadt, Jared ;
Endy, Timothy P. ;
Srikiatkhachorn, Anon ;
Thaisomboonsuk, Butsaya ;
Klungthong, Chonticha ;
Nisalak, Ananda ;
Khuntirat, Benjawan ;
Jarman, Richard G. ;
Fernandez, Stefan ;
Thomas, Stephen J. ;
Scott, Thomas W. ;
Rothman, Alan L. ;
Yoon, In-Kyu .
PLOS NEGLECTED TROPICAL DISEASES, 2014, 8 (10)
[4]   ANTIGENIC RELATIONSHIPS BETWEEN FLAVIVIRUSES AS DETERMINED BY CROSS-NEUTRALIZATION TESTS WITH POLYCLONAL ANTISERA [J].
CALISHER, CH ;
KARABATSOS, N ;
DALRYMPLE, JM ;
SHOPE, RE ;
PORTERFIELD, JS ;
WESTAWAY, EG ;
BRANDT, WE .
JOURNAL OF GENERAL VIROLOGY, 1989, 70 :37-43
[5]  
Chau Tran Nguyen Bich, 2008, J Infect Dis, V198, P516, DOI 10.1086/590117
[6]   A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus (vol 16, pg 171, 2015) [J].
Dejnirattisai, Wanwisa ;
Wongwiwat, Wiyada ;
Supasa, Sunpetchuda ;
Zhang, Xiaokang ;
Dai, Xinghong ;
Rouvinsky, Alexander ;
Jumnainsong, Amonrat ;
Edwards, Carolyn ;
Nguyen Than Ha Quyen ;
Duangchinda, Thaneeya ;
Grimes, Jonathan M. ;
Tsai, Wen-Yang ;
Lai, Chih-Yun ;
Wang, Wei-Kung ;
Malasit, Prida ;
Farrar, Jeremy ;
Simmons, Cameron P. ;
Zhou, Z. Hong ;
Rey, Felix A. ;
Mongkolsapaya, Juthathip ;
Screaton, Gavin R. .
NATURE IMMUNOLOGY, 2015, 16 (07) :785-785
[7]   Emergence potential of sylvatic dengue virus type 4 in the urban transmission cycle is restrained by vaccination and homotypic immunity [J].
Durbin, Anna P. ;
Mayer, Sandra V. ;
Rossi, Shannan L. ;
Amaya-Larios, Irma Y. ;
Ramos-Castaneda, Jose ;
Ooi, Eng Eong ;
Cardosa, M. Jane ;
Munoz-Jordan, Jorge L. ;
Tesh, Robert B. ;
Messer, William B. ;
Weaver, Scott C. ;
Vasilakis, Nikos .
VIROLOGY, 2013, 439 (01) :34-41
[8]   Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3′-untranslated region [J].
Durbin, AP ;
Karron, RA ;
Sun, W ;
Vaughn, DW ;
Reynolds, MJ ;
Perreault, JR ;
Thumar, B ;
Men, R ;
Lai, CJ ;
Elkins, WR ;
Chanock, RM ;
Murphy, BR ;
Whitehead, SS .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2001, 65 (05) :405-413
[9]   Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand [J].
Endy, TP ;
Nisalak, A ;
Chunsuttitwat, S ;
Vaughn, DW ;
Green, S ;
Ennis, FA ;
Rothman, AL ;
Libraty, DH .
JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (06) :990-1000
[10]   IDENTIFICATION OF DISTINCT ANTIGENIC DETERMINANTS ON DENGUE-2 VIRUS USING MONOCLONAL-ANTIBODIES [J].
GENTRY, MK ;
HENCHAL, EA ;
MCCOWN, JM ;
BRANDT, WE ;
DALRYMPLE, JM .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1982, 31 (03) :548-555