Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

被引：76

作者：

Chae, Pil Seok ^{[1
]}

Rana, Rohini R. ^{[2
]}

Gotfryd, Kamil ^{[3
]}

Rasmussen, Soren G. F. ^{[4
]}

Kruse, Andrew C. ^{[4
]}

Cho, Kyung Ho ^{[1
]}

Capaldi, Stefano ^{[2
]}

Carlsson, Emil ^{[2
]}

Kobilka, Brian ^{[4
]}

Loland, Claus J. ^{[3
]}

Gether, Ulrik ^{[3
]}

Banerjee, Surajit ^{[5
]}

Byrne, Bernadette ^{[2
]}

Lee, John K. ^{[6
]}

Gellman, Samuel H. ^{[7
]}

机构：

[1] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea

[2] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England

[3] Univ Copenhagen, Dept Neurosci & Pharmacol, DK-2200 Copenhagen, Denmark

[4] Stanford Univ, Stanford, CA 94305 USA

[5] Cornell Univ, NE CAT, Argonne, IL 60439 USA

[6] Univ Minnesota, Dept Biochem, Minneapolis, MN 55455 USA

[7] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 23期

基金：

新加坡国家研究基金会;

关键词：

FACIAL AMPHIPHILES; DETERGENT; STABILIZATION; RECEPTOR; SOLUBILIZATION; CRYSTALLIZATION; SURFACTANTS; STABILITY; PEPTIDE;

D O I：

10.1039/c2cc36844g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

引用

页码：2287 / 2289

页数：3

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