Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

被引：79

作者：

Chae, Pil Seok ^{[1
]}

Rana, Rohini R. ^{[2
]}

Gotfryd, Kamil ^{[3
]}

Rasmussen, Soren G. F. ^{[4
]}

Kruse, Andrew C. ^{[4
]}

Cho, Kyung Ho ^{[1
]}

Capaldi, Stefano ^{[2
]}

Carlsson, Emil ^{[2
]}

Kobilka, Brian ^{[4
]}

Loland, Claus J. ^{[3
]}

Gether, Ulrik ^{[3
]}

Banerjee, Surajit ^{[5
]}

Byrne, Bernadette ^{[2
]}

Lee, John K. ^{[6
]}

Gellman, Samuel H. ^{[7
]}

机构：

[1] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea

[2] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England

[3] Univ Copenhagen, Dept Neurosci & Pharmacol, DK-2200 Copenhagen, Denmark

[4] Stanford Univ, Stanford, CA 94305 USA

[5] Cornell Univ, NE CAT, Argonne, IL 60439 USA

[6] Univ Minnesota, Dept Biochem, Minneapolis, MN 55455 USA

[7] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 23期

基金：

新加坡国家研究基金会;

关键词：

FACIAL AMPHIPHILES; DETERGENT; STABILIZATION; RECEPTOR; SOLUBILIZATION; CRYSTALLIZATION; SURFACTANTS; STABILITY; PEPTIDE;

D O I：

10.1039/c2cc36844g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

引用

页码：2287 / 2289

页数：3

共 45 条

[1] Microscale fluorescent thermal stability assay for membrane proteins [J].

Alexandrov, Alexander I. ;

Mileni, Mauro ;

Chien, Ellen Y. T. ;

Hanson, Michael A. ;

Stevens, Raymond C. .

STRUCTURE, 2008, 16 (03) :351-359

[2] Stabilizing membrane proteins [J].

Bowie, JU .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2001, 11 (04) :397-402

[3] Hemifluorinated surfactants: a non-dissociating environment for handling membrane proteins in aqueous solutions? [J].

Breyton, C ;

Chabaud, E ;

Chaudier, Y ;

Pucci, B ;

Popot, JL .

FEBS LETTERS, 2004, 564 (03) :312-318

[4] Membrane Protein Structure Determination Using Crystallography and Lipidic Mesophases: Recent Advances and Successes [J].

Caffrey, Martin ;

Li, Dianfan ;

Dukkipati, Abhiram .

BIOCHEMISTRY, 2012, 51 (32) :6266-6288

[5] Glycotripod amphiphiles for solubilization and stabilization of a membrane-protein superassembly: Importance of branching in the hydrophilic portion [J].

Chae, Pil S. ;

Wander, Marc J. ;

Bowling, Aaron P. ;

Laible, Philip D. ;

Gellman, Samuel H. .

CHEMBIOCHEM, 2008, 9 (11) :1706-1709

[6] A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins [J].

Chae, Pil Seok ;

Rasmussen, Soren G. F. ;

Rana, Rohini R. ;

Gotfryd, Kamil ;

Kruse, Andrew C. ;

Manglik, Aashish ;

Cho, Kyung Ho ;

Nurva, Shailika ;

Gether, Ulrik ;

Guan, Lan ;

Loland, Claus J. ;

Byrne, Bernadette ;

Kobilka, Brian K. ;

Gellman, Samuel H. .

CHEMISTRY-A EUROPEAN JOURNAL, 2012, 18 (31) :9485-9490

[7] Tandem Facial Amphiphiles for Membrane Protein Stabilization [J].

Chae, Pil Seok ;

Gotfryd, Kamil ;

Pacyna, Jennifer ;

Miercke, Larry J. W. ;

Rasmussen, Soren G. F. ;

Robbins, Rebecca A. ;

Rana, Rohini R. ;

Loland, Claus J. ;

Kobilka, Brian ;

Stroud, Robert ;

Byrne, Bernadette ;

Gether, Ulrik ;

Gellman, Samuel H. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (47) :16750-16752

[8] Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins [J].

Chae, Pil Seok ;

Rasmussen, Soren G. F. ;

Rana, Rohini R. ;

Gotfryd, Kamil ;

Chandra, Richa ;

Goren, Michael A. ;

Kruse, Andrew C. ;

Nurva, Shailika ;

Loland, Claus J. ;

Pierre, Yves ;

Drew, David ;

Popot, Jean-Luc ;

Picot, Daniel ;

Fox, Brian G. ;

Guan, Lan ;

Gether, Ulrik ;

Byrne, Bernadette ;

Kobilka, Brian ;

Gellman, Samuel H. .

NATURE METHODS, 2010, 7 (12) :1003-U90

[9] FLUORIMETRIC DETERMINATION OF CRITICAL MICELLE CONCENTRATION AVOIDING INTERFERENCE FROM DETERGENT CHARGE [J].

CHATTOPADHYAY, A ;

LONDON, E .

ANALYTICAL BIOCHEMISTRY, 1984, 139 (02) :408-412

[10] The complete genome of the hyperthermophilic bacterium Aquifex aeolicus [J].

Deckert, G ;

Warren, PV ;

Gaasterland, T ;

Young, WG ;

Lenox, AL ;

Graham, DE ;

Overbeek, R ;

Snead, MA ;

Keller, M ;

Aujay, M ;

Huber, R ;

Feldman, RA ;

Short, JM ;

Olsen, GJ ;

Swanson, RV .

NATURE, 1998, 392 (6674) :353-358

← 1 2 3 4 5 →