Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-β

被引：50

作者：

Lim, Yen Ying ^{[1
]}

Pietrzak, Robert H. ^{[3
]}

Ellis, Kathryn A. ^{[1
,2
,4
]}

Jaeger, Judith ^{[5
,6
]}

Harrington, Karra ^{[1
]}

Ashwood, Tim ^{[7
]}

Szoeke, Cassandra ^{[1
,4
,8
]}

Martins, Ralph N. ^{[9
]}

Bush, Ashley I. ^{[1
,10
]}

Masters, Colin L. ^{[1
]}

Rowe, Christopher C. ^{[11
,12
,13
]}

Villemagne, Victor L. ^{[1
,11
,12
]}

Ames, David ^{[4
]}

Darby, David ^{[1
,14
,15
]}

Maruff, Paul ^{[1
,14
,15
]}

机构：

[1] Univ Melbourne, Mental Hlth Res Inst, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Psychiat, Acad Unit Psychiat Old Age, Parkville, Vic 3052, Australia

[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[4] Natl Ageing Res Inst, Parkville, Vic, Australia

[5] Albert Einstein Coll Med, Bronx, NY 10467 USA

[6] CogState Ltd, New Haven, CT USA

[7] AstraZeneca R&D, Global Med Dev, Sodertalje, Sweden

[8] CSIRO Preventat Hlth Flagship, Parkville, Vic, Australia

[9] Edith Cowan Univ, Sch Exercise Biomed & Hlth Sci, Ctr Excellence Alzheimers Dis Res & Care, Perth, WA, Australia

[10] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia

[11] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia

[12] Austin Hlth, Ctr PET, Heidelberg, Vic, Australia

[13] Univ Melbourne, Dept Med, Austin Hlth, Heidelberg, Vic, Australia

[14] Univ Melbourne, Florey Neurosci Inst, Carlton, Vic, Australia

[15] CogState Ltd, Melbourne, Vic, Australia

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 33卷 / 03期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; amyloid-beta; cognitive decline; episodic memory; neuropsychological assessment; COGNITIVE DECLINE; A-BETA; ASSOCIATION; BIOMARKERS;

D O I：

10.3233/JAD-2012-121516

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

High levels of amyloid-beta (A beta) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of A beta-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of A beta. High A beta was associated with greater decline in episodic memory measures over 6 months in healthy older adults.

引用

页码：675 / 679

页数：5

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