Atropine prevents the changes in the hindlimb cortical area induced by hypodynamia-hypokinesia

被引：6

作者：

Dupont, E ^{[1
]}

Canu, MH ^{[1
]}

Falempin, M ^{[1
]}

机构：

[1] Univ Sci & Tech Lille Flandres Artois, Lab Plast Neuromusculaire, F-59655 Villeneuve Dascq, France

来源：

BRAIN RESEARCH | 2002年 / 926卷 / 1-2期

关键词：

plasticity; cortical reorganization; rat brain; somatosensory cortex; receptive field; sensory deprivation;

D O I：

10.1016/S0006-8993(01)03293-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been demonstrated that hypodynamia-hypokinesia (HH), a model of sensory disruption, induced a decrease in the cortical hindpaw representation and an enlargement of the cutaneous receptive fields (RFs). The present study was carried out to determine whether chronic application of atropine could prevent this reorganisation. The extent of the hindlimb representation on the somatosensory cortex was determined in control rats (C), rats submitted to HH (HH), and rats submitted to HH with a chronic cortical infusion of atropine (70 mM, HH-ATR). Our results show that the hindpaw cortical area was similar for the HH-ATR and C rats, and was smaller for the HH rats. The distribution of RFs was comparable for the C and HH-ATR groups with a high percentage of small RFs. In contrast, for the HH rats, the percentage of large RFs was higher. Atropine can thus prevent the reduction in the hindlimb cortical area induced by HH. These results suggest that cholinergic mechanisms contribute to cortical plasticity. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：51 / 57

页数：7

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