Paclitaxel Potentiates the Anticancer Effect of Cetuximab by Enhancing Antibody-Dependent Cellular Cytotoxicity on Oral Squamous Cell Carcinoma Cells In Vitro

被引：13

作者：

Sawatani, Yuta ^{[1
]}

Komiyama, Yuske ^{[1
,2
]}

Nakashiro, Koh-ichi ^{[3
]}

Uchida, Daisuke ^{[3
]}

Fukumoto, Chonji ^{[1
]}

Shimura, Michiko ^{[1
]}

Hasegawa, Tomonori ^{[1
]}

Kamimura, Ryouta ^{[1
]}

Hitomi-Koide, Masayo ^{[1
]}

Hyodo, Toshiki ^{[1
]}

Kawamata, Hitoshi ^{[1
]}

机构：

[1] Dokkyo Med Univ, Dept Oral & Maxillofacial Surg, Sch Med, 880 Kita Kobayashi, Shimo Tsuga, Tochigi 3210293, Japan

[2] Sano Kosei Gen Hosp, Sect Dent & Oral & Maxillofacial Surg, 1728 Horigomecho, Sano, Tochigi 3278511, Japan

[3] Ehime Univ, Dept Oral & Maxillofacial Surg, Grad Sch Med, Toon, Ehime 7910295, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 17期

关键词：

antibody-dependent cellular cytotoxicity (ADCC); cetuximab; paclitaxel; synergistic effects; oral squamous cell carcinoma (OSCC); epidermal growth factor receptor (EGFR); EPIDERMAL-GROWTH-FACTOR; FACTOR RECEPTOR; HEAD; EXPRESSION; INVASION; LINES;

D O I：

10.3390/ijms21176292

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Administration of cetuximab (C-mab) in combination with paclitaxel (PTX) has been used for patients with head and neck squamous cell carcinoma (SCC) clinically. In this study, we attempted to clarify the molecular mechanisms of the enhancing anticancer effect of C-mab combined with PTX on oral SCC cells in vitro. We used two oral SCC cells (HSC4, OSC19) and A431 cells. PTX alone inhibited cell growth in all cells in a concentration-dependent manner. C-mab alone inhibited the growth of A431 and OSC19 cells at low concentrations, but inhibited the growth of HSC4 cells very weakly, even at high concentrations. A combined effect of the two drugs was moderate on A431 cells, but slight on HSC4 and OSC19 cells. A low concentration of PTX enhanced the antibody-dependent cellular cytotoxicity (ADCC) induced by C-mab in all of the cells tested. PTX slightly enhanced the anticancer effect of C-mab in this ADCC model on A431 and HSC4 cells, and markedly enhanced the anticancer effect of C-mab on OSC19 cells. These results indicated that PTX potentiated the anticancer effect of C-mab through enhancing the ADCC in oral SCC cells.

引用

页码：1 / 11

页数：11

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