EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders

被引：94

作者：

Boyman, O. ^{[1
]}

Kaegi, C. ^{[1
]}

Akdis, M. ^{[2
,3
]}

Bavbek, S. ^{[4
]}

Bossios, A. ^{[5
]}

Chatzipetrou, A. ^{[6
]}

Eiwegger, T. ^{[7
]}

Firinu, D. ^{[8
]}

Harr, T. ^{[9
]}

Knol, E. ^{[10
,11
]}

Matucci, A. ^{[12
]}

Palomares, O. ^{[13
]}

Schmidt-Weber, C. ^{[14
,15
]}

Simon, H-U. ^{[16
]}

Steiner, U. C. ^{[17
]}

Vultaggio, A. ^{[12
]}

Akdis, C. A. ^{[2
,3
]}

Spertini, F. ^{[18
]}

机构：

[1] Univ Zurich, Dept Immunol, Univ Zurich Hosp, CH-8091 Zurich, Switzerland

[2] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[3] CK CARE, Davos, Switzerland

[4] Ankara Univ, Dept Pulm Dis, Div Immunol & Allergy, Sch Med, TR-06100 Ankara, Turkey

[5] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Krefting Res Ctr,Dept Internal Med & Nutr, Gothenburg, Sweden

[6] Univ Athens, Allergy Unit D Kalogeromitros, Dept Dermatol & Venerol 2, Attikon Univ Hosp,Med Sch, Athens, Greece

[7] Med Univ Vienna, Dept Pediat & Adolescent Med, Vienna, Austria

[8] Univ Cagliari, Unit Internal Med Allergy & Clin Immunol, Dept Med Sci M Aresu, Monserrato, Italy

[9] Hop Univ Genev, Specialites Med, Serv Immunol & Allergol, Geneva, Switzerland

[10] Univ Med Ctr Utrecht, Dept Immunol, Utrecht, Netherlands

[11] Univ Med Ctr Utrecht, Dept Dermatol Allergol, Utrecht, Netherlands

[12] Azienda Osped Univ Careggi, Dept Biomed, Immunoallergol Unit, Florence, Italy

[13] Univ Complutense Madrid, Dept Biochem & Mol Biol, Sch Chem, Madrid, Spain

[14] Tech Univ Munich, Ctr Allergy & Environm ZAUM, D-80290 Munich, Germany

[15] Helmholtz Ctr Munich, Munich, Germany

[16] Univ Bern, Inst Pharmacol, Bern, Switzerland

[17] Spitalnetz Bern Tiefenau Ziegler, Div Allergol & Clin Immunol, Bern, Switzerland

[18] CHU Vaudois, Div Immunol & Allergy, Lausanne, Switzerland

来源：

ALLERGY | 2015年 / 70卷 / 07期

基金：

瑞士国家科学基金会;

关键词：

allergic rhinitis; asthma; atopic dermatitis; eosinophilic disorders; food allergy; hymenoptera allergy; urticaria; NECROSIS-FACTOR-ALPHA; ANTI-CD20 RITUXIMAB TREATMENT; CHRONIC AUTOIMMUNE URTICARIA; ADAPTIVE IMMUNE-RESPONSES; SEVERE ATOPIC-DERMATITIS; SEVERE PERSISTENT ASTHMA; INDUCED AIRWAY RESPONSES; LONG-TERM SAFETY; ANTI-IGE; MONOCLONAL-ANTIBODY;

D O I：

10.1111/all.12616

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Biologic agents (also termed biologicals or biologics) are therapeutics that are synthesized by living organisms and directed against a specific determinant, for example, a cytokine or receptor. In inflammatory and autoimmune diseases, biologicals have revolutionized the treatment of several immune-mediated disorders. Biologicals have also been tested in allergic disorders. These include agents targeting IgE; T helper 2 (Th2)-type and Th2-promoting cytokines, including interleukin-4 (IL-4), IL-5, IL-9, IL-13, IL-31, and thymic stromal lymphopoietin (TSLP); pro-inflammatory cytokines, such as IL-1, IL-12, IL-17A, IL-17F, IL-23, and tumor necrosis factor (TNF); chemokine receptor CCR4; and lymphocyte surface and adhesion molecules, including CD2, CD11a, CD20, CD25, CD52, and OX40 ligand. In this task force paper of the Interest Group on Biologicals of the European Academy of Allergy and Clinical Immunology, we review biologicals that are currently available or tested for the use in various allergic and urticarial pathologies, by providing an overview on their state of development, area of use, adverse events, and future research directions.

引用

页码：727 / 754

页数：28

共 181 条

[41] A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma [J].