Self-assembly and Self-replication of Short Amphiphilic β-sheet Peptides

被引:18
|
作者
Bourbo, Valery [1 ]
Matmor, Maayan [2 ]
Shtelman, Elina [1 ]
Rubinov, Boris [1 ]
Ashkenasy, Nurit [2 ,3 ]
Ashkenasy, Gonen [1 ]
机构
[1] Ben Gurion Univ Negev, Dept Chem, Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Dept Mat Engn, IL-84105 Beer Sheva, Israel
[3] Ben Gurion Univ Negev, Ilze Katz Inst Nanoscale Sci & Technol, IL-84105 Beer Sheva, Israel
来源
基金
欧洲研究理事会;
关键词
Prebiotic peptides; Self-replication; beta-sheets; TEMPLATES; NETWORKS; ORIGIN; WORLD; LIFE;
D O I
10.1007/s11084-011-9257-y
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Most self-replicating peptide systems are made of alpha-helix forming sequences. However, it has been postulated that shorter and simpler peptides may also serve as templates for replication when arranged into well-defined structures. We describe here the design and characterization of new peptides that form soluble beta-sheet aggregates that serve to significantly accelerate their ligation and self-replication. We then discuss the relevance of these phenomena to early molecular evolution, in light of additional functionality associated with beta-sheet assemblies.
引用
收藏
页码:563 / 567
页数:5
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