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Self-assembly and Self-replication of Short Amphiphilic β-sheet Peptides
被引:18
|作者:
Bourbo, Valery
[1
]
Matmor, Maayan
[2
]
Shtelman, Elina
[1
]
Rubinov, Boris
[1
]
Ashkenasy, Nurit
[2
,3
]
Ashkenasy, Gonen
[1
]
机构:
[1] Ben Gurion Univ Negev, Dept Chem, Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Dept Mat Engn, IL-84105 Beer Sheva, Israel
[3] Ben Gurion Univ Negev, Ilze Katz Inst Nanoscale Sci & Technol, IL-84105 Beer Sheva, Israel
来源:
基金:
欧洲研究理事会;
关键词:
Prebiotic peptides;
Self-replication;
beta-sheets;
TEMPLATES;
NETWORKS;
ORIGIN;
WORLD;
LIFE;
D O I:
10.1007/s11084-011-9257-y
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Most self-replicating peptide systems are made of alpha-helix forming sequences. However, it has been postulated that shorter and simpler peptides may also serve as templates for replication when arranged into well-defined structures. We describe here the design and characterization of new peptides that form soluble beta-sheet aggregates that serve to significantly accelerate their ligation and self-replication. We then discuss the relevance of these phenomena to early molecular evolution, in light of additional functionality associated with beta-sheet assemblies.
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页码:563 / 567
页数:5
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