Self-assembly and Self-replication of Short Amphiphilic β-sheet Peptides

被引：18

作者：

Bourbo, Valery ^{[1
]}

Matmor, Maayan ^{[2
]}

Shtelman, Elina ^{[1
]}

Rubinov, Boris ^{[1
]}

Ashkenasy, Nurit ^{[2
,3
]}

Ashkenasy, Gonen ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Dept Chem, Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Dept Mat Engn, IL-84105 Beer Sheva, Israel

[3] Ben Gurion Univ Negev, Ilze Katz Inst Nanoscale Sci & Technol, IL-84105 Beer Sheva, Israel

来源：

ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES | 2011年 / 41卷 / 06期

基金：

欧洲研究理事会;

关键词：

Prebiotic peptides; Self-replication; beta-sheets; TEMPLATES; NETWORKS; ORIGIN; WORLD; LIFE;

D O I：

10.1007/s11084-011-9257-y

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most self-replicating peptide systems are made of alpha-helix forming sequences. However, it has been postulated that shorter and simpler peptides may also serve as templates for replication when arranged into well-defined structures. We describe here the design and characterization of new peptides that form soluble beta-sheet aggregates that serve to significantly accelerate their ligation and self-replication. We then discuss the relevance of these phenomena to early molecular evolution, in light of additional functionality associated with beta-sheet assemblies.

引用

页码：563 / 567

页数：5

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