Significance of Exhaled Nitric Oxide and Carbon Monoxide in Auxiliary Diagnosis and Evaluation of Allergic Rhinitis

被引：3

作者：

Zhao, Chuanliang ^{[1
,2
]}

Qin, Mali ^{[1
,2
]}

Jin, Ling ^{[1
,2
]}

Lai, Ju ^{[1
,2
]}

Wang, Yang ^{[1
,2
]}

Liu, Shuangxi ^{[1
,2
]}

Yu, Shaoqing ^{[1
,2
]}

机构：

[1] Tongji Univ, Tongji Hosp, Sch Med, Dept Otolaryngol Head & Neck Surg, Shanghai 200065, Peoples R China

[2] Tongji Univ, Tongji Hosp, Sch Med, Dept Allergy, Shanghai 200065, Peoples R China

来源：

MEDIATORS OF INFLAMMATION | 2022年 / 2022卷

基金：

美国国家科学基金会;

关键词：

CHILDREN; ASTHMA; NASAL; ASSOCIATION;

D O I：

10.1155/2022/2083057

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Objective. The concentration of exhaled NO and CO is considered as a candidate marker of respiratory inflammatory disease. This report discusses the exhaled NO and CO in the auxiliary diagnosis and evaluation of allergic rhinitis (AR). Methods. 60 AR patients from October 2017 to March 2019, compared with 30 healthy controls. The severity of AR disease was distinguished by symptom score. Both groups were tested for exhaled nitric oxide through the nose or mouth and exhale carbon monoxide through the mouth. AR patients received glucocorticoid nasal spray for 1 month and were tested again for nNO, eNO, eCO, and symptom score. Results. Before treatment, all the nNO, eNO, and eCO of the AR group were higher than the control group. There were differences in the severe and moderate subgroup: severe > moderate > mild. eCO was not significantly different between the mild and control groups. The nNO, eNO, and eCO levels were positively correlated with symptom score. After treatment, nNO decreased significantly in the three subgroups; eNO and eCO in the severe AR group decreased significantly. Drawing the ROC curve, the area under curve (AUC) of nNO is 0.978. The AUC of eNO and eCO was 0.786 and 0.577, respectively. Conclusion. The nNO, eNO, and eCO in the AR group are higher than healthy people, which positively correlated with the severity of AR symptoms. The detection of nNO, eNO, and eCO can monitor the changes of AR. The detection of nNO level as an indicator of AR auxiliary diagnosis has high accuracy.

引用

页数：10