RNase III enzymes and the initiation of gene silencing

被引：305
作者：
Carmell, MA
Hannon, GJ
机构：
[1] Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
[2] SUNY Stony Brook, Genet Program, Stony Brook, NY 11794 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 03期
关键词：
D O I：
10.1038/nsmb729
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Our understanding of RNA interference has been enhanced by new data concerning RNase III molecules. The role of Dicer has previously been established in RNAi as the originator of 22-mers characteristic of silencing phenomena. Recently, a related RNAse III enzyme, Drosha, has surfaced as another component of the RNAi pathway. In addition to biochemistry, protein structures have proven to be helpful in deciphering the enzymology of RNase III molecules.
引用
收藏
页码：214 / 218
页数：5
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