Natalizumab modulates the humoral response against HERV-Wenv73-88 in a follow-up study of Multiple Sclerosis patients

被引：12

作者：

Arru, Giannina ^{[1
]}

Caggiu, Elisa ^{[1
]}

Leoni, Stefania ^{[2
]}

Mameli, Giuseppe ^{[1
]}

Pugliatti, Maura ^{[2
]}

Sechi, Gian Pietro ^{[2
]}

Sechi, Leonardo A. ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Sci Biomed, Sez Microbiol, I-07100 Sassari, Italy

[2] Univ Sassari, Dipartimento Med Clin Sperimentale, I-07100 Sassari, Italy

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2015年 / 357卷 / 1-2期

关键词：

Multiple Sclerosis; Natalizumab therapy; HERV-Wenv; Epstein Barr Virus (EBV); Mycobacterium avium ss. paratuberculosis (MAP); Antibodies; ELISA; AVIUM SUBSP PARATUBERCULOSIS; EPSTEIN-BARR-VIRUS; RETROVIRUS; EXPRESSION; BLOOD;

D O I：

10.1016/j.jns.2015.07.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple Sclerosis (MS) is a heterogeneous disorder of the central nervous system (CNS) that begins as an inflammatory autoimmune disorder mediated by auto-reactive lymphocyte followed by microglial activation and chronic degeneration. The etiology of Multiple Sclerosis (MS) is unknown but several data support the hypothesis of possible infectious agents which may act as a trigger for the pathogenic cascade. Human endogenous retrovirus (HERV-W/MSRV), Epstein Barr Virus (EBV) and Mycobacterium avium ss. paratuberculosis (MAP) have been associated to Multiple Sclerosis. In this study, we evaluated the humoral response against different peptides: the human endogenous retrovirus HERV-Wenv(73-88), MAP106c(121-132) from MAP, EBNA1 (400-413) from EBV and the homologous human peptide MBP85-98 in a cohort of MS patients treated with natalizumab. Results showed a statistically significant difference in the response against the HERV-W peptide in MS patients after two years of natalizumab treatment. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：106 / 108

页数：3

共 13 条

[11] Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF [J].

Warnke, Clemens ;

Stettner, Mark ;

Lehmensiek, Vera ;

Dehmel, Thomas ;

Mausberg, Anne K. ;

von Geldern, Gloria ;

Gold, Ralf ;

Kuempfel, Tania ;

Hohlfeld, Reinhard ;

Maeurer, Mathias ;

Stangel, Martin ;

Straeten, Vera ;

Limmroth, Volker ;

Weber, Thomas ;

Kleinschnitz, Christoph ;

Wattjes, Mike P. ;

Svenningsson, Anders ;

Olsson, Tomas ;

Hartung, Hans-Peter ;

Hermsen, Derik ;

Tumani, Hayrettin ;

Adams, Ortwin ;

Kieseier, Bernd C. .

MULTIPLE SCLEROSIS JOURNAL, 2015, 21 (08) :1036-1044

[12] Changes to anti-JCV antibody levels in a Swedish national MS cohort [J].

Warnke, Clemens ;

Ramanujam, Ryan ;

Plavina, Tatiana ;

Bergstrom, Tomas ;

Goelz, Susan ;

Subramanyam, Meena ;

Kockum, Ingrid ;

Rahbar, Afsar ;

Kieseier, Bernd C. ;

Holmen, Carolina ;

Olsson, Tomas ;

Hillert, Jan ;

Fogdell-Hahn, Anna .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2013, 84 (11) :1199-1205

[13] Adhesion molecules are promising candidates to establish surrogate markers for natalizumab treatment [J].

Wipfler, P. ;

Oppermann, K. ;

Pilz, G. ;

Afazel, S. ;

Haschke-Becher, E. ;

Harrer, A. ;

Huemer, M. ;

Kunz, A. ;

Golaszewski, S. ;

Staffen, W. ;

Ladurner, G. ;

Kraus, J. .

MULTIPLE SCLEROSIS, 2011, 17 (01) :16-23

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