Natalizumab modulates the humoral response against HERV-Wenv73-88 in a follow-up study of Multiple Sclerosis patients

被引:12
作者
Arru, Giannina [1 ]
Caggiu, Elisa [1 ]
Leoni, Stefania [2 ]
Mameli, Giuseppe [1 ]
Pugliatti, Maura [2 ]
Sechi, Gian Pietro [2 ]
Sechi, Leonardo A. [1 ]
机构
[1] Univ Sassari, Dipartimento Sci Biomed, Sez Microbiol, I-07100 Sassari, Italy
[2] Univ Sassari, Dipartimento Med Clin Sperimentale, I-07100 Sassari, Italy
关键词
Multiple Sclerosis; Natalizumab therapy; HERV-Wenv; Epstein Barr Virus (EBV); Mycobacterium avium ss. paratuberculosis (MAP); Antibodies; ELISA; AVIUM SUBSP PARATUBERCULOSIS; EPSTEIN-BARR-VIRUS; RETROVIRUS; EXPRESSION; BLOOD;
D O I
10.1016/j.jns.2015.07.007
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Multiple Sclerosis (MS) is a heterogeneous disorder of the central nervous system (CNS) that begins as an inflammatory autoimmune disorder mediated by auto-reactive lymphocyte followed by microglial activation and chronic degeneration. The etiology of Multiple Sclerosis (MS) is unknown but several data support the hypothesis of possible infectious agents which may act as a trigger for the pathogenic cascade. Human endogenous retrovirus (HERV-W/MSRV), Epstein Barr Virus (EBV) and Mycobacterium avium ss. paratuberculosis (MAP) have been associated to Multiple Sclerosis. In this study, we evaluated the humoral response against different peptides: the human endogenous retrovirus HERV-Wenv(73-88), MAP106c(121-132) from MAP, EBNA1 (400-413) from EBV and the homologous human peptide MBP85-98 in a cohort of MS patients treated with natalizumab. Results showed a statistically significant difference in the response against the HERV-W peptide in MS patients after two years of natalizumab treatment. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:106 / 108
页数:3
相关论文
共 13 条
[1]   Natalizumab inhibits the expression of human endogenous retroviruses of the W family in multiple sclerosis patients: a longitudinal cohort study [J].
Arru, Giannina ;
Leoni, Stefania ;
Pugliatti, Maura ;
Mei, Alessandra ;
Serra, Caterina ;
Delogu, Lucia Gemma ;
Manetti, Roberto ;
Dolei, Antonina ;
Sotgiu, Stefano ;
Mameli, Giuseppe .
MULTIPLE SCLEROSIS JOURNAL, 2014, 20 (02) :174-182
[2]  
Cossu D, 2013, FUTURE MICROBIOL, V8, P223, DOI [10.2217/fmb.12.135, 10.2217/FMB.12.135]
[3]   Are Mycobacterium avium subsp paratuberculosis and Epstein-Barr virus triggers of multiple sclerosis in Sardinia? [J].
Cossu, Davide ;
Masala, Speranza ;
Cocco, Eleonora ;
Paccagnini, Daniela ;
Frau, Jessica ;
Marrosu, Maria Giovanna ;
Sechi, Leonardo A. .
MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (08) :1181-1184
[4]   Infectious causes of multiple sclerosis [J].
Giovannoni, Gavin ;
Cutter, Gary R. .
LANCET NEUROLOGY, 2006, 5 (10) :887-889
[5]   Epstein-Barr virus and Mycobacterium avium subsp paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patients [J].
Mameli, Giuseppe ;
Cossu, Davide ;
Cocco, Eleonora ;
Masala, Speranza ;
Frau, Jessica ;
Marrosu, Maria Giovanna ;
Sechi, Leonardo A. .
JOURNAL OF NEUROIMMUNOLOGY, 2014, 270 (1-2) :51-55
[6]   Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease [J].
Perron, Herve ;
Germi, Raphaelle ;
Bernard, Corinne ;
Garcia-Montojo, Marta ;
Deluen, Cecile ;
Farinelli, Laurent ;
Faucard, Raphael ;
Veas, Francisco ;
Stefas, Ilias ;
Fabriek, Babs O. ;
Van-Horssen, Jack ;
Van-der-Valk, Paul ;
Gerdil, Claire ;
Mancuso, Roberta ;
Saresella, Marina ;
Clerici, Mario ;
Marcel, Sebastien ;
Creange, Alain ;
Cavaretta, Rosella ;
Caputo, Domenico ;
Arru, Giannina ;
Morand, Patrice ;
Lang, Alois B. ;
Sotgiu, Stefano ;
Ruprecht, Klemens ;
Rieckmann, Peter ;
Villoslada, Pablo ;
Chofflon, Michel ;
Boucraut, Jose ;
Pelletier, Jean ;
Hartung, Hans-Peter .
MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (12) :1721-1736
[7]   Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria [J].
Polman, Chris H. ;
Reingold, Stephen C. ;
Banwell, Brenda ;
Clanet, Michel ;
Cohen, Jeffrey A. ;
Filippi, Massimo ;
Fujihara, Kazuo ;
Havrdova, Eva ;
Hutchinson, Michael ;
Kappos, Ludwig ;
Lublin, Fred D. ;
Montalban, Xavier ;
O'Connor, Paul ;
Sandberg-Wollheim, Magnhild ;
Thompson, Alan J. ;
Waubant, Emmanuelle ;
Weinshenker, Brian ;
Wolinsky, Jerry S. .
ANNALS OF NEUROLOGY, 2011, 69 (02) :292-302
[8]   Mycobacterium avium ss. paratuberculosis Zoonosis The Hundred Year War - Beyond Crohn's Disease [J].
Sechi, Leonardo A. ;
Dow, Coad Thomas .
FRONTIERS IN IMMUNOLOGY, 2015, 6
[9]   Natalizumab treatment decreases serum IgM and IgG levels in multiple sclerosis patients [J].
Selter, Rebecca C. ;
Biberacher, Viola ;
Grummel, Verena ;
Buck, Dorothea ;
Eienbroeker, Christian ;
Oertel, Wolfgang H. ;
Berthele, Achim ;
Tackenberg, Bjoern ;
Hemmer, Bernhard .
MULTIPLE SCLEROSIS JOURNAL, 2013, 19 (11) :1454-1461
[10]   Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis [J].
Sotgiu, S. ;
Mameli, G. ;
Serra, C. ;
Zarbo, I. R. ;
Arru, G. ;
Dolei, A. .
MULTIPLE SCLEROSIS, 2010, 16 (10) :1248-1251