Facile Regioselective Synthesis of a Novel Chitosan-Pexiganan Conjugate with Potential Interest for the Treatment of Infected Skin Lesions

被引：10
作者：
Batista, Mary K. S. [1 ,2 ]
Gallemi, Marcal [1 ]
Adeva, Alberto [3 ]
Gomes, Carlos A. R. [2 ]
Gomes, Paula [1 ]
机构：
[1] Univ Porto, Fac Ciencias, Dept Quim, CIQUP, P-4169007 Oporto, Portugal
[2] Univ Porto, Fac Ciencias, Dept Quim, LAQUIPAI, P-4169007 Oporto, Portugal
[3] Univ Barcelona, Unitat Sintesi Peptids, Serv Cientificotecn, Barcelona, Spain
来源：
SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 07期
关键词：
Antimicrobials; biopolymers; chitosan; diabetes; drug delivery; peptides; pexiganan; MELITTIN HYBRID PEPTIDES; SECONDARY STRUCTURE; DERIVATIVES; MEMBRANES; HYDROGELS; DELIVERY; BEHAVIOR;
D O I：
10.1080/00397910802517855
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A pexiganan-chitosan conjugate was designed to combine the exceptional bioadhesion and tissue-regenerating abilities of chitosan with the excellent antibiotic properties of pexiganan. We herein report our first results on the successful synthesis, including Fourier transform infrared (FT-IR) and amino acid analysis of such conjugate, which was prepared by regioselective covalent attachment of a Cys-containing pexiganan analog to the chitosan's amino groups. Further results from ongoing research will be reported.
引用
收藏
页码：1228 / 1240
页数：13
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