Molecular mechanisms of cytodifferentiation in mammalian tooth development

被引:45
作者
Tompkins, Kevin
机构
[1] Northwestern Univ, Feinberg Sch Med, Dept Cell & Mol Biol, Chicago, IL USA
[2] Univ Illinois, Coll Med, Dept Anat & Cell Biol, Chicago, IL USA
[3] Univ Illinois, Coll Dent, Dept Oral Biol, Chicago, IL USA
关键词
ameloblast; cytodifferentiation; growth factor; odontoblast; tooth development;
D O I
10.1080/03008200600727756
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The morphological stages of tooth development-bud, cap, bell, and terminal differentiation-have been known for decades. The past 10 years have seen the elucidation of many of the molecular events driving these morphogenetic stages. Signaling via the fibroblast growth factor (FGF), bone morphogenetic protein (BMP), hedgehog, and wingless protein families and their downstream transcription factors have been identified as key players in the epithelial-mesenchymal signaling loops driving tooth development. Currently the most complete description of the mechanisms in tooth development extends only through the cap stage. The body of work concerning the mechanisms directing the bell and cytodifferentiation stages is growing. This has mainly, but not exclusively, focused on the expression and effects of FGFs and BMPs in these latter stages, and is reviewed here. Additionally, recent results suggest that phenotypic proteins of both ameloblasts and odontoblasts, such as amelogenin and dentin matrix protein 2 may act as the final instructive signals in cytodifferentiation.
引用
收藏
页码:111 / 118
页数:8
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