Modest efficacy of voriconazole against murine infections by Sporothrix schenckii and lack of efficacy against Sporothrix brasiliensis

被引：21
|
作者：
Fernandez-Silva, Fabiola [1 ]
Capilla, Javier [2 ]
Mayayo, Emilio [1 ]
Guarro, Josep [2 ]
机构：
[1] Univ Rovira & Virgili, Unitat Anat Patol, Fac Med & Ciencies Salut, E-43201 Reus, Spain
[2] Univ Rovira & Virgili, IISPV, Fac Med & Ciencies Salut, E-43201 Reus, Spain
来源：
MYCOSES | 2014年 / 57卷 / 02期
关键词：
Voriconazole; sporotrichosis; animal model; IN-VITRO; DISSEMINATED SPOROTRICHOSIS; SUSCEPTIBILITY; POSACONAZOLE; ITRACONAZOLE; INVOLVEMENT; VALUES; AGENTS;
D O I：
10.1111/myc.12112
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The efficacy of voriconazole (VRC) was evaluated against two strains of each of the two most common species causing sporotrichosis, Sporothrix schenckii sensu stricto and Sporothrix brasiliensis, using a murine model of disseminated infection. Voriconazole was administered at doses of 20 or 40mgkg(-1) per day by gavage. The drug showed some efficacy, especially at 40mgkg(-1) per day, in prolonging the survival and reducing fungal load in spleen and liver in mice infected with S. schenckii, whereas in animals infected with S. brasiliensis the drug did not work.
引用
收藏
页码：121 / 124
页数：4
相关论文
共 50 条
  • [41] Anti-inflammatory activity of Vismia guianensis (Aubl.) Pers. extracts and antifungal activity against Sporothrix schenckii
    Oliveira, A. H.
    de Oliveira, G. G.
    Carnevale Neto, F.
    Portuondo, D. F.
    Batista-Duharte, A.
    Carlos, I. Z.
    JOURNAL OF ETHNOPHARMACOLOGY, 2017, 195 : 266 - 274
  • [42] In vitro efficacy of the combination of voriconazole and anidulafungin against voriconazole-resistant cyp51A mutants of Aspergillus fumigatus
    Krishnan-Natesan, Suganthini
    Wu, Wenjuan
    Chandrasekar, Pranatharthi H.
    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2012, 73 (02) : 135 - 137
  • [43] Soil samples from sporotrichosis transmission belt area: Searching for fungal species and their antagonistic activity against Sporothrix brasiliensis
    da Costa, Gisela Lara
    Ferreira, Isabella Escorcio
    Correa-Moreira, Danielly
    Marinho, Anna
    de Almeida, Adilson Benedito
    Pereira, Sandro Antonio
    Borba, Cintia Moraes
    Evangelista Oliveira, Manoel Marques
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 12
  • [44] In vitro evaluation of the cis-[Ru(phen)2(pPDIp)]2+** complex for antimicrobial photodynamic therapy against Sporothrix brasiliensis and Candida albicans
    Tiburcio, M. A.
    Rocha, A. R.
    Romano, R. A.
    Inada, N. M.
    Bagnato, V. S.
    Carlos, R. M.
    Buzza, H. H.
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2022, 229
  • [45] Therapeutic efficacy of posaconazole against Candida glabrata in a murine model of vaginitis
    Gonzalez, Gloria M.
    Elizondo, Mariana
    Garza-Gonzalez, Elvira
    Gerardo Gonzalez, J.
    MYCOSES, 2011, 54 (02) : 119 - 122
  • [46] Efficacy of Voriconazole against Aspergillus fumigatus Infection Depends on Host Immune Function
    Rosowski, Emily E.
    He, Jiaye
    Huisken, Jan
    Keller, Nancy P.
    Huttenlocher, Anna
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (02)
  • [47] Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole
    dos Santos Velasco de Souza, Lais Cavalcanti
    Reis, Nathalia Faria
    Alcantara, Lucas Martins
    Leal da Silveira Souto, Simone Rocha
    de Araujo Penna, Bruno
    Souza Santos, Renan Caetano
    Robbs, Bruno Kaufmann
    Machado, Francisco Paiva
    Castro, Helena Carla
    Dantas Machado, Ricardo Luiz
    Rocha, Leandro
    de Souza Baptista, Andrea Regina
    BRAZILIAN JOURNAL OF MICROBIOLOGY, 2023, 54 (01) : 579 - 586
  • [48] Efficacy of liposomal amphotericin against febrile neutropenia in pediatric patients receiving prophylactic voriconazole
    Kobayashi, Ryoji
    Matsushima, Satoru
    Hori, Daiki
    Sano, Hirozumi
    Suzuki, Daisuke
    Kishimoto, Kenji
    Nakano, Takaaki
    Yanagi, Masato
    Kodama, Kouya
    Kobayashi, Kunihiko
    PEDIATRICS INTERNATIONAL, 2021, 63 (05) : 550 - 555
  • [49] Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole
    Lais Cavalcanti dos Santos Velasco de Souza
    Nathália Faria Reis
    Lucas Martins Alcântara
    Simone Rocha Leal da Silveira Souto
    Bruno de Araújo Penna
    Renan Caetano Souza Santos
    Bruno Kaufmann Robbs
    Francisco Paiva Machado
    Helena Carla Castro
    Ricardo Luiz Dantas Machado
    Leandro Rocha
    Andréa Regina de Souza Baptista
    Brazilian Journal of Microbiology, 2023, 54 : 579 - 586
  • [50] Modified dosing schedule efficacy of fosmidomycin and clindamycin against murine malaria Plasmodium berghei
    Walker, Leah A.
    Bagonza, Vision
    Bobb, Bryce
    Sullivan, David J.
    INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE, 2025, 27
12345