Modest efficacy of voriconazole against murine infections by Sporothrix schenckii and lack of efficacy against Sporothrix brasiliensis

被引：21
|
作者：
Fernandez-Silva, Fabiola [1 ]
Capilla, Javier [2 ]
Mayayo, Emilio [1 ]
Guarro, Josep [2 ]
机构：
[1] Univ Rovira & Virgili, Unitat Anat Patol, Fac Med & Ciencies Salut, E-43201 Reus, Spain
[2] Univ Rovira & Virgili, IISPV, Fac Med & Ciencies Salut, E-43201 Reus, Spain
来源：
MYCOSES | 2014年 / 57卷 / 02期
关键词：
Voriconazole; sporotrichosis; animal model; IN-VITRO; DISSEMINATED SPOROTRICHOSIS; SUSCEPTIBILITY; POSACONAZOLE; ITRACONAZOLE; INVOLVEMENT; VALUES; AGENTS;
D O I：
10.1111/myc.12112
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The efficacy of voriconazole (VRC) was evaluated against two strains of each of the two most common species causing sporotrichosis, Sporothrix schenckii sensu stricto and Sporothrix brasiliensis, using a murine model of disseminated infection. Voriconazole was administered at doses of 20 or 40mgkg(-1) per day by gavage. The drug showed some efficacy, especially at 40mgkg(-1) per day, in prolonging the survival and reducing fungal load in spleen and liver in mice infected with S. schenckii, whereas in animals infected with S. brasiliensis the drug did not work.
引用
收藏
页码：121 / 124
页数：4
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