Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules

被引：25

作者：

Fadaei, Reza ^{[1
,7
,8
]}

Dadmanesh, Maryam ^{[2
]}

Moradi, Nariman ^{[3
,4
]}

Ahmadi, Reza ^{[5
]}

Shokoohi Nahrkhalaji, Abolfazl ^{[4
]}

Aghajani, Hassan ^{[6
]}

Ghorban, Khodayar ^{[1
]}

机构：

[1] Aja Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[2] Aja Univ Med Sci, Sch Med, Dept Infect Dis, Tehran, Iran

[3] Kurdistan Univ Med Sci, Fac Med, Dept Clin Biochem, Sanandaj, Iran

[4] Iran Univ Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran

[5] Shahrekord Univ Med Sci, Basic Hlth Sci Inst, Clin Biochem Res Ctr, Shahrekord, Iran

[6] Univ Tehran Med Sci, Tehran Heart Ctr, Intervent Cardiol Dept, Tehran, Iran

[7] Kermanshah Univ Med Sci, Sleep Disorders Res Ctr, Kermanshah, Iran

[8] Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2020年 / 126卷 / 04期

关键词：

Subfatin; meteorin-like; ICAM-1; VCAM-1; E-selectin; endothelial dysfunction; METEORIN-LIKE; INSULIN-RESISTANCE; INFLAMMATION; ADIPOKINES;

D O I：

10.1080/13813455.2018.1538248

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Subfatin is a newly discovered adipokine with insulin-sensitizing properties. Studies reported conflicting data with regard to the circulating levels and expression of Subfatin in the context of type 2 diabetes mellitus (T2DM) and obesity. The present study was conducted on 52 patients with T2DM, 36 prediabetes subjects, and 50 controls. The serum levels of Subfatin, adhesion molecules were measured by the ELISA technique. The serum Subfatin was lower in the T2DM and prediabetes groups. The serum levels of adhesion molecules were higher in the T2DM group. In addition, Subfatin demonstrated lower levels in obese patients with T2DM in comparison to lean T2DM patients. Furthermore, Subfatin showed a negative association with vascular adhesion molecules in prediabetes subjects and the T2DM group. A decrease in the serum Subfatin in T2DM patients and prediabetes subjects, and its association with vascular adhesion molecules suggested the possible role of Subfatin in diabetes and endothelial dysfunction.

引用

页码：335 / 340

页数：6

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