Emergence of Autochthonous Infections with Hepatitis E Virus of Genotype 4 in Europe

被引：65

作者：

Bouamra, Yanis ^{[1
]}

Gerolami, Rene ^{[3
]}

Arzouni, Jean-Pierre ^{[1
]}

Grimaud, Jean-Charles ^{[4
]}

Lafforgue, Pierre ^{[5
]}

Nelli, Marjorie ^{[6
]}

Tivoli, Natacha ^{[1
]}

Ferretti, Audrey ^{[1
]}

Motte, Anne ^{[1
]}

Colson, Philippe ^{[1
,2
]}

机构：

[1] Ctr Hosp Univ Timone, Federat Bacteriol Hyg Virol, Pole Malad Infect & Trop Clin & Biol, IHU Mediterranee Infect,AP HM, Marseille, France

[2] Aix Marseille Univ, Fac Med & Pharm, CNRS, INSERM,U1095,URMITE UM 63,IRD 198, Marseille, France

[3] Ctr Hosp Univ Concept, Serv HepatoGastroenterol, AP HM, Marseille, France

[4] Ctr Hosp Univ Nord, AP HM, Serv Hepatogastroenterol, Marseille, France

[5] Ctr Hosp Univ St Marguerite, AP HM, Serv Rhumatol, Marseille, France

[6] Ctr Hosp Salon, Serv Hepatogastroenterol, Salon De Provence, France

来源：

INTERVIROLOGY | 2014年 / 57卷 / 01期

关键词：

Hepatitis E virus; Genotype; 4; France; Laboratory-based surveillance; Zoonosis; PHYLOGENETIC ANALYSIS; FULMINANT-HEPATITIS; RISK-FACTORS; FOOD-BORNE; PIG-LIVER; FRANCE; TRANSMISSION; DIVERSITY; EPIDEMIOLOGY; CIRCULATION;

D O I：

10.1159/000354801

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In Europe, autochthonous hepatitis E is caused by genotype 3 hepatitis E virus (HEV) in almost all cases. A total of 15 infections with genotype 4 HEV were diagnosed in France from May 2009 to April 2012, and all but one of the HEV-4 strains implicated in these infections were genetically related and highly similar to HEV-4 sequences isolated from swine in Belgium. In addition, 5 autochthonous HEV-4 infections have been described in the region of Lazio, Italy, during March and April 2011, and these HEV sequences were 100% identical to one another but showed relatively low similarity (74-85%) to HEV-4 RNA samples collected in France. We report 6 additional HEV-4 infections that were diagnosed from May to July 2012 which represented 50% of the HEV infections diagnosed during this period in our clinical microbiology laboratory. Five of these HEV-4 strains were associated with autochthonous infections and were clustered together and with the majority of HEV-4 previously described in France, whereas the sixth strain was genetically divergent. Taken together with reports from other teams, these observations indicate that autochthonous infections with HEV-4 are emerging in Europe and have been transmitted by at least two distinct sources. (C) 2013 S. Karger AG, Basel

引用

页码：43 / 48

页数：6

共 31 条

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