Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels

被引：47
作者：
Severino, Paolo [1 ]
D'Amato, Andrea [1 ]
Netti, Lucrezia [1 ]
Pucci, Mariateresa [1 ]
De Marchis, Marialaura [1 ]
Palmirotta, Raffaele [2 ,3 ]
Volterrani, Maurizio [4 ]
Mancone, Massimo [1 ]
Fedele, Francesco [1 ]
机构：
[1] Sapienza Univ Rome, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, I-00161 Rome, Italy
[2] Aldo Moro Univ Bari, Dept Biomed Sci, I-70124 Bari, Italy
[3] Aldo Moro Univ Bari, Clin Oncol Oncogen Res Ctr, I-70124 Bari, Italy
[4] IRCCS San Raffaele, Dept Cardiac Rehabil, I-00163 Rome, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 03期
关键词：
ion channels; coronary blood flow; diabetes mellitus; ischemic heart disease; ACTIVATED POTASSIUM CHANNELS; VASCULAR SMOOTH-MUSCLE; CORONARY MICROVASCULAR DYSFUNCTION; CA2+-ACTIVATED K+ CHANNEL; K(CA)3.1 CHANNELS; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; HYDROGEN-PEROXIDE; CELL-MIGRATION; NITRIC-OXIDE;
D O I：
10.3390/ijms19030802
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients. In particular, some genetic variants for ATP-dependent potassium channels seem to be involved in the determinism of IHD.
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页数：20
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