Azole antifungal drugs induce cell death by suppressing mTOR through PI3K/Akt inhibition in human breast cancer

被引:0
|
作者
Park, Ju Ho [1 ]
Kim, Hyesook [2 ]
Kim, So Hee [1 ]
机构
[1] Ajou Univ, Suwon, South Korea
[2] Detroit R&D, Detroit, MI USA
关键词
D O I
10.1158/1538-7445.AM2018-2327
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2327
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway
    Wang, Feng
    Mao, Yong
    You, Qingjun
    Hua, Dong
    Cai, Dongyan
    INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2015, 28 (03) : 362 - 373
  • [22] Myricetin induces apoptosis and autophagy in human gastric cancer cells through inhibition of the PI3K/Akt/mTOR pathway
    Han, So-Hee
    Lee, Jae-Han
    Woo, Joong-Seok
    Jung, Gi-Hwan
    Jung, Soo-Hyun
    Han, Eun-Ji
    Kim, Bumseok
    Cho, Sung Dae
    Nam, Jeong Seok
    Che, Jeong Hwan
    Jung, Ji-Youn
    HELIYON, 2022, 8 (05)
  • [23] Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways
    Kandil, Emad
    Tsumagari, Koji
    Ma, Jingjing
    Elmageed, Zakaria Y. Abd
    Li, Xinying
    Slakey, Douglas
    Mondal, Debasis
    Abdel-Mageed, Asim B.
    JOURNAL OF SURGICAL RESEARCH, 2013, 184 (02) : 898 - 906
  • [24] Inhibition of the PI3K/AKT/mTOR pathway in pancreatic cancer: is it a worthwhile endeavor?
    Ouissam, Al Jarroudi
    Hind, Chibani
    Aziz, Brahmi Sami
    Said, Afqir
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2024, 16
  • [25] Activation of PI3K/Akt/mTOR Pathway and Dual Inhibitors of PI3K and mTOR in Endometrial Cancer
    Chen, Jiezhong
    Zhao, Kong-Nan
    Li, Rui
    Shao, Renfu
    Chen, Chen
    CURRENT MEDICINAL CHEMISTRY, 2014, 21 (26) : 3070 - 3080
  • [26] Inhibition of MTor Through AMPK Activation and PI3K/Akt Inhibition is Important to Docosahexaenoic Acid-induced Cell Death in Human Non-small Cell Lung Cancer Cells
    Lim, K.
    Kim, N.
    Jing, K.
    Jeong, S.
    Shin, S.
    Oh, H.
    Heo, J. Y.
    Park, J. I.
    Yoon, W. H.
    Hwang, B. D.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S33 - S33
  • [27] CENPF facilitates endometrial cancer cell progression through PI3K/AKT/mTOR pathway
    Xiao, Huan
    Zhang, Zhi'an
    Wei, Chunqing
    Peng, Dan
    Guo, Yuge
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2023, 44 (01) : 106 - 114
  • [28] Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells
    Hong-Wei Zhang
    Jin-Jiao Hu
    Ruo-Qiu Fu
    Xin Liu
    Yan-Hao Zhang
    Jing Li
    Lei Liu
    Yu-Nong Li
    Qin Deng
    Qing-Song Luo
    Qin Ouyang
    Ning Gao
    Scientific Reports, 8
  • [29] Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells
    Zhang, Hong-Wei
    Hu, Jin-Jiao
    Fu, Ruo-Qiu
    Liu, Xin
    Zhang, Yan-Hao
    Li, Jing
    Liu, Lei
    Li, Yu-Nong
    Deng, Qin
    Luo, Qing-Song
    Ouyang, Qin
    Gao, Ning
    SCIENTIFIC REPORTS, 2018, 8
  • [30] The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers
    Paplomata, Elisavet
    O'Regan, Ruth
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2014, 6 (04) : 154 - 166