TSPAN33 is a novel marker of activated and malignant B cells

被引：24

作者：

Luu, Van Phi ^{[1
,2
]}

Hevezi, Peter ^{[1
,2
]}

Vences-Catalan, Felipe ^{[3
]}

Maravillas-Montero, Jose Luis ^{[1
,2
]}

White, Clayton Alexander ^{[2
,4
]}

Casali, Paolo ^{[2
,4
]}

Llorente, Luis ^{[5
]}

Jakez-Ocampo, Juan ^{[5
]}

Lima, Guadalupe ^{[5
]}

Vilches-Cisneros, Natalia ^{[6
]}

Pablo Flores-Gutierrez, Juan ^{[6
]}

Santos-Argumedo, Leopoldo ^{[3
]}

Zlotnik, Albert ^{[1
,2
]}

机构：

[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Inst Immunol, Irvine, CA 92697 USA

[3] CINVESTAV IPN, Dept Mol Biomed, Mexico City, DF, Mexico

[4] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

[5] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol, Mexico City, DF, Mexico

[6] Univ Autonoma Nuevo Leon, Univ Hosp, Serv Anat Pathol, Monterrey, NL, Mexico

来源：

CLINICAL IMMUNOLOGY | 2013年 / 149卷 / 03期

关键词：

Tetraspanin; 33; B cells; Lymphoma; Lupus erythematosus; Rheumatoid arthritis; Biomarker; EARLY RHEUMATOID-ARTHRITIS; SWITCH DNA RECOMBINATION; SYSTEMIC AUTOIMMUNITY; ANTI-CD20; ANTIBODY; DISEASE-ACTIVITY; AID EXPRESSION; TETRASPANIN; LYMPHOMA; GENE; RITUXIMAB;

D O I：

10.1016/j.clim.2013.08.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B Cells following activation. Human 2E2 cells; a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Fas(lpr/lpr) mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：388 / 399

页数：12

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