TSPAN33 is a novel marker of activated and malignant B cells

被引：24

作者：

Luu, Van Phi ^{[1
,2
]}

Hevezi, Peter ^{[1
,2
]}

Vences-Catalan, Felipe ^{[3
]}

Maravillas-Montero, Jose Luis ^{[1
,2
]}

White, Clayton Alexander ^{[2
,4
]}

Casali, Paolo ^{[2
,4
]}

Llorente, Luis ^{[5
]}

Jakez-Ocampo, Juan ^{[5
]}

Lima, Guadalupe ^{[5
]}

Vilches-Cisneros, Natalia ^{[6
]}

Pablo Flores-Gutierrez, Juan ^{[6
]}

Santos-Argumedo, Leopoldo ^{[3
]}

Zlotnik, Albert ^{[1
,2
]}

机构：

[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Inst Immunol, Irvine, CA 92697 USA

[3] CINVESTAV IPN, Dept Mol Biomed, Mexico City, DF, Mexico

[4] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

[5] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol, Mexico City, DF, Mexico

[6] Univ Autonoma Nuevo Leon, Univ Hosp, Serv Anat Pathol, Monterrey, NL, Mexico

来源：

CLINICAL IMMUNOLOGY | 2013年 / 149卷 / 03期

关键词：

Tetraspanin; 33; B cells; Lymphoma; Lupus erythematosus; Rheumatoid arthritis; Biomarker; EARLY RHEUMATOID-ARTHRITIS; SWITCH DNA RECOMBINATION; SYSTEMIC AUTOIMMUNITY; ANTI-CD20; ANTIBODY; DISEASE-ACTIVITY; AID EXPRESSION; TETRASPANIN; LYMPHOMA; GENE; RITUXIMAB;

D O I：

10.1016/j.clim.2013.08.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B Cells following activation. Human 2E2 cells; a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Fas(lpr/lpr) mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：388 / 399

页数：12

共 69 条

[1] EXPRESSION OF HUMAN B CELL-ASSOCIATED ANTIGENS ON LEUKEMIAS AND LYMPHOMAS - A MODEL OF HUMAN B-CELL DIFFERENTIATION
ANDERSON, KC
BATES, MP
SLAUGHENHOUPT, BL
PINKUS, GS
SCHLOSSMAN, SF
NADLER, LM
[J]. BLOOD, 1984, 63 (06) : 1424 - 1433
[2] [Anonymous], PLOS ONE
[3] B-cell targeted therapeutics in clinical development
Blueml, Stephan
McKeever, Kathleen
Ettinger, Rachel
Smolen, Josef
Herbst, Ronald
[J]. ARTHRITIS RESEARCH & THERAPY, 2013, 15
[4] DERIVATION OF THE SLEDAI - A DISEASE-ACTIVITY INDEX FOR LUPUS PATIENTS
BOMBARDIER, C
GLADMAN, DD
UROWITZ, MB
CARON, D
CHANG, CH
[J]. ARTHRITIS AND RHEUMATISM, 1992, 35 (06): : 630 - 640
[5] Regulatory B cells as inhibitors of immune responses and inflammation
Bouaziz, Jean-David
Yanaba, Koichi
Tedder, Thomas F.
[J]. IMMUNOLOGICAL REVIEWS, 2008, 224 : 201 - 214
[6] B-Cell Stimulatory Cytokines and Markers of Immune Activation Are Elevated Several Years Prior to the Diagnosis of Systemic AIDS-Associated Non-Hodgkin B-Cell Lymphoma
Breen, Elizabeth Crabb
Hussain, Shehnaz K.
Magpantay, Larry
Jacobson, Lisa P.
Detels, Roger
Rabkin, Charles S.
Kaslow, Richard A.
Variakojis, Daina
Bream, Jay H.
Rinaldo, Charles R.
Ambinder, Richard F.
Martinez-Maza, Otoniel
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2011, 20 (07) : 1303 - 1314
[7] CXCL17 Is a Mucosal Chemokine Elevated in Idiopathic Pulmonary Fibrosis That Exhibits Broad Antimicrobial Activity
Burkhardt, Amanda M.
Tai, Kenneth P.
Flores-Guiterrez, Juan P.
Vilches-Cisneros, Natalia
Kamdar, Karishma
Barbosa-Quintana, Oralia
Valle-Rios, Ricardo
Hevezi, Peter A.
Zuniga, Joaquin
Selman, Moises
Ouellette, Andre J.
Zlotnik, Albert
[J]. JOURNAL OF IMMUNOLOGY, 2012, 188 (12) : 6399 - 6406
[8] A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
Chan, OTM
Hannum, LG
Haberman, AM
Madaio, MP
Shlomchik, MJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (10) : 1639 - 1647
[9] Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis
Choy, Ernest
[J]. RHEUMATOLOGY, 2012, 51 : V3 - V11
[10] LPR AND GLD - SINGLE GENE MODELS OF SYSTEMIC AUTOIMMUNITY AND LYMPHOPROLIFERATIVE DISEASE
COHEN, PL
EISENBERG, RA
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 : 243 - 269

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