Intravitreal Dexamethasone Implant as a Sustained Release Drug Delivery Device for the Treatment of Ocular Diseases: A Comprehensive Review of the Literature

被引：43

作者：

Iovino, Claudio ^{[1
]}

Mastropasqua, Rodolfo ^{[2
]}

Lupidi, Marco ^{[3
,4
,5
]}

Bacherini, Daniela ^{[6
]}

Pellegrini, Marco ^{[7
]}

Bernabei, Federico ^{[7
]}

Borrelli, Enrico ^{[8
]}

Sacconi, Riccardo ^{[8
]}

Carnevali, Adriano ^{[9
]}

D'Aloisio, Rossella ^{[10
]}

Cerquaglia, Alessio ^{[3
]}

Finocchio, Lucia ^{[6
,11
]}

Govetto, Andrea ^{[12
,13
]}

Erba, Stefano ^{[12
]}

Triolo, Giacinto ^{[12
]}

Di Zazzo, Antonio ^{[14
]}

Forlini, Matteo ^{[15
]}

Vagge, Aldo ^{[16
]}

Giannaccare, Giuseppe ^{[9
]}

机构：

[1] Univ Cagliari, Dept Surg Sci, Eye Clin, I-09124 Cagliari, Italy

[2] Univ Modena & Reggio Emilia, Inst Ophthalmol, I-41121 Modena, Italy

[3] Univ Perugia, S Maria della Misericordia Hosp, Dept Surg & Biomed Sci, Sect Ophthalmol, I-06129 Perugia, Italy

[4] Fdn Macula Onlus, Univ Eye Clin, DINOMGI, I-16132 Genoa, Italy

[5] Ctr Odeon, 113 Blvd St Germain, F-75006 Paris, France

[6] Univ Florence, AOU Careggi, Dept Neurosci Psychol Drug Res & Child Hlth, Eye Clin, I-50139 Florence, Italy

[7] Univ Bologna, S Orsola Malpighi Univ Hosp, Ophthalmol Unit, I-40138 Bologna, Italy

[8] Univ Vita Salute San Raffaele, Hosp San Raffaele, Dept Ophthalmol, I-20132 Milan, Italy

[9] Magna Graecia Univ Catanzaro, Dept Ophthalmol, I-88100 Catanzaro, Italy

[10] Univ G dAnnunzio, Dept Med & Sci Ageing, Ophthalmol Clin, I-66100 Chieti, Italy

[11] Moorfields Eye Hosp NHS Fdn Trust, London EC1V 2PD, England

[12] ASST Fatebenefratelli Sacco, Fatebenefratelli Oftalm Hosp, I-63631 Milan, Italy

[13] Univ Hosp Bristol NHS Fdn Trust, Bristol Eye Hosp, Bristol BS1 2LX, Avon, England

[14] Campus Bio Med Univ Hosp, Ophthalmol Complex Operat Unit, I-00128 Rome, Italy

[15] Domus Nova Hosp, I-48121 Ravenna, Italy

[16] Polyclin Hosp San Martino IRCCS, Univ Eye Clin, DINOGMI, I-16132 Genoa, Italy

来源：

PHARMACEUTICS | 2020年 / 12卷 / 08期

关键词：

corticosteroids; drug delivery systems; intravitreal dexamethasone implant; intravitreal injections; Ozurdex; DIABETIC MACULAR EDEMA; RETINAL VEIN OCCLUSION; ANTI-VEGF INJECTIONS; RETINITIS-PIGMENTOSA; INTRAOCULAR-PRESSURE; NONINFECTIOUS INTERMEDIATE; VITRECTOMIZED EYES; CLINICAL-OUTCOMES; SUBGROUP ANALYSIS; GRAFT-REJECTION;

D O I：

10.3390/pharmaceutics12080703

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drug delivery into the vitreous chamber remains a great challenge in the pharmaceutical industry due to the complex anatomy and physiology of the eye. Intravitreal injection is the mainstream route of drug administration to the posterior segment of the eye. The purpose of this review is to assess the current literature about the widening use of the intravitreal 0.7 mg dexamethasone (Dex) implant, and to provide a comprehensive collection of all the ocular disorders that benefit from Dex administration. Although anti-vascular endothelial growth-factors (VEGFs) have been largely indicated as a first-choice level, the Dex implant represents an important treatment option, especially in selected cases, such as vitrectomized eyes or patients in whom anti-VEGF failed or are contraindicated. In this article, the safety profile as well as the list of the possible complications related to intravitreal Dex injection are also discussed.

引用

页码：1 / 26

页数：26

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