Tumour Regression Induced by Co-administration of MIP-3αand CpG in an Experimental Model of Colon Carcinoma

被引：4

作者：

Arab, S. ^{[1
]}

Mojarrad, M. ^{[2
]}

Motamedi, M. ^{[3
]}

Mirzaei, R. ^{[1
]}

Modarressi, M. H. ^{[4
]}

Hadjati, J. ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran 1417613151, Iran

[2] Mashhad Univ Med Sci, Dept Med Genet, Fac Med, Mashhad, Iran

[3] Lorestan Univ Med Sci, Khorramabad, Iran

[4] Univ Tehran Med Sci, Dept Human Genet, Sch Med, Tehran, Iran

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2013年 / 78卷 / 01期

关键词：

DENDRITIC CELL TRAFFICKING; ANTITUMOR IMMUNITY; LYMPHOID ORGANS; CHEMOKINES; GROWTH; GENERATION; IMMUNOTHERAPY; VACCINATION; ACTIVATION; INJECTION;

D O I：

10.1111/sji.12058

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CCL20/macrophage inflammatory protein-3 (MIP-3) represents one of the potent chemoattractive proteins for dendritic cells (DCs). Herein, we investigated whether in vivo genetic modification of tumour cells aimed at intratumoural production of MIP-3 might lead to accumulation of DCs in tumour tissue. Mice injected with CT26, received recombinant adenovirus (Ad) vectors (AdMIP-3) expressing MIP-3 protein. This was complemented by injections of CpG. Interestingly, MIP-3 gene therapy combined with CpG injections resulted in specific cytotoxicity. This was associated with significant suppression of tumour growth rate. These findings demonstrate the potential of strategies that utilize in vivo overexpression of chemokines.

引用

页码：28 / 34

页数：7

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