Forkhead box proteins: tuning forks for transcriptional harmony

被引：559
作者：
Lam, Eric W. -F. [1 ]
Brosens, Jan J. [2 ]
Gomes, Ana R. [1 ]
Koo, Chuay-Yeng [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Imperial Ctr Translat & Expt Med ICTEM, London W12 0NN, England
[2] Univ Hosp, Div Reprod Hlth, Warwick Med Sch, Clin Sci Res Labs, Coventry CV2 2DX, W Midlands, England
来源：
NATURE REVIEWS CANCER | 2013年 / 13卷 / 07期
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; ESTROGEN-RECEPTOR-ALPHA; BREAST-CANCER CELLS; ANDROGEN RECEPTOR; HISTONE DEACETYLASES; FOXM1; EXPRESSION; PROSTATE-CANCER; SUPPRESSOR GENE; FACTOR FOXO3A; ER-ALPHA;
D O I：
10.1038/nrc3539
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers.
引用
收藏
页码：482 / 495
页数：14
相关论文
共 196 条
[81]   Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells [J].
Kong, Dejuan ;
Banerjee, Sanjeev ;
Ahmad, Aamir ;
Li, Yiwei ;
Wang, Zhiwei ;
Sethi, Seema ;
Sarkar, Fazlul H. .
PLOS ONE, 2010, 5 (08)
[82]   Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state [J].
Kong, Say Li ;
Li, Guoliang ;
Loh, Siang Lin ;
Sung, Wing-Kin ;
Liu, Edison T. .
MOLECULAR SYSTEMS BIOLOGY, 2011, 7
[83]   FOXM1: From cancer initiation to progression and treatment [J].
Koo, Chuay-Yeng ;
Muir, Kyle W. ;
Lam, Eric W. -F. .
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2012, 1819 (01) :28-37
[84]   The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells [J].
Krol, Janna ;
Francis, Richard E. ;
Albergaria, Andre ;
Sunters, Andrew ;
Polychronis, Andreas ;
Coombes, R. Charles ;
Lam, Eric W. -F. .
MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) :3169-3179
[85]  
Kume T, 2009, ADV EXP MED BIOL, V665, P63
[86]   FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells [J].
Kwok, Jimmy M. -M. ;
Peck, Barrie ;
Monteiro, Lara J. ;
Schwenen, Helma D. C. ;
Millour, Julie ;
Coombes, R. Charles ;
Myatt, Stephen S. ;
Lam, Eric W. -F. .
MOLECULAR CANCER RESEARCH, 2010, 8 (01) :24-34
[87]   Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression [J].
Kwok, Jimmy M-M. ;
Myatt, Stephen S. ;
Marson, Charles M. ;
Coombes, R. Charles ;
Constantinidou, Demetra ;
Lam, Eric W-F. .
MOLECULAR CANCER THERAPEUTICS, 2008, 7 (07) :2022-2032
[88]   Three Novel Acetylation Sites in the Foxp3 Transcription Factor Regulate the Suppressive Activity of Regulatory T Cells [J].
Kwon, Hye-Sook ;
Lim, Hyung W. ;
Wu, Jessica ;
Schnoelzer, Martina ;
Verdin, Eric ;
Ott, Melanie .
JOURNAL OF IMMUNOLOGY, 2012, 188 (06) :2712-2721
[89]   Activation of FoxM1 during G2 requires cyclin A/cdk-dependent relief of autorepression by the FoxM1 N-terminal domain [J].
Laoukili, Jamila ;
Alvarez, Monica ;
Meijer, Lars A. T. ;
Stahl, Marie ;
Mohammed, Shabaz ;
Kleij, Livio ;
Heck, Albert J. R. ;
Medema, Rene H. .
MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (09) :3076-3087
[90]   The initiation of liver development is dependent on Foxa transcription factors [J].
Lee, CS ;
Friedman, JR ;
Fulmer, JT ;
Kaestner, KH .
NATURE, 2005, 435 (7044) :944-947
45678910111213