Forkhead box proteins: tuning forks for transcriptional harmony

被引：559

作者：

Lam, Eric W. -F. ^{[1
]}

Brosens, Jan J. ^{[2
]}

Gomes, Ana R. ^{[1
]}

Koo, Chuay-Yeng ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Imperial Ctr Translat & Expt Med ICTEM, London W12 0NN, England

[2] Univ Hosp, Div Reprod Hlth, Warwick Med Sch, Clin Sci Res Labs, Coventry CV2 2DX, W Midlands, England

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 07期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; ESTROGEN-RECEPTOR-ALPHA; BREAST-CANCER CELLS; ANDROGEN RECEPTOR; HISTONE DEACETYLASES; FOXM1; EXPRESSION; PROSTATE-CANCER; SUPPRESSOR GENE; FACTOR FOXO3A; ER-ALPHA;

D O I：

10.1038/nrc3539

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers.

引用

页码：482 / 495

页数：14

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