Antidiabetic and Immunoprophylactic Effects of Camel Milk Filtrate and Bitter Gourd (Momordica charantia) Juice Against Alloxan-induced Oxidative Stress and Diabetes in Rats

Background and Objective: The increasing of environmental pollution and changing of the dietary habits and other lifestyle are associated with increasing the risk factors and oxidative stress. Dairy manipulation and traditional plant therapies are commonly prescribed in various countries.Therefore,the aim of the present study was to investigate the antidiabeticand immunoprophylactic effect of a combination of camel milkfiltrate with bitter gourd (Momordica charantia). Materials and Methods: Fresh camel milk was subjected to membrane filtration system and milk filtrate was used. Bitter gourd was cut into small size cubes and put in a high speed electric blender to make juice. The biological evaluation of camel milk filtrate and bitter gourd juice against alloxan-induced diabetic rats were studied. The immunological analyses and some blood biochemical markers were carried out using official methods. Results: Administration of camel milk filtrate and bitter gourd juice showed a hypoglycemic and immunoprophylactic effect. Blood glucose levels were decreased in alloxan-induced diabetic rats fed on camel milk filtrate and bitter gourd juice groups compared with alloxan-induced diabetic group fed on basal diet (positive control). In addition, ad ministration of camel milkfiltrate and bitter gourd juice was associated with a reduction in the serum levels of Alanine aminotransaminase (ALT) and Aspartate aminotransaminase (AST), when compared with positive control. Conclusion: Administration of camel milk filtrate and bitter gourd juice could have hypoglycemic effect in alloxan-induced diabetic rats.This immunoprophylactic and protective effect probably due to micronutrients found in the combination and synergistic effect of camel milk filtrate and bitter gourd against oxidative stress and diabetes.