A high-dose preparation of lactobacilli and bifidobacteria in the prevention of antibiotic-associated and Clostridium difficile diarrhoea in older people admitted to hospital: a multicentre, randomised, double-blind, placebo-controlled, parallel arm trial (PLACIDE)

被引:0
作者
Allen, S. J. [1 ]
Wareham, K. [2 ]
Wang, D. [3 ]
Bradley, C. [4 ]
Sewell, B. [5 ]
Hutchings, H. [1 ]
Harris, W. [6 ]
Dhar, A. [4 ]
Brown, H. [4 ]
Foden, A. [4 ]
Gravenor, M. B. [1 ]
Mack, D. [1 ,7 ]
Phillips, C. J. [5 ]
机构
[1] Swansea Univ, Coll Med, Swansea, W Glam, Wales
[2] Morriston Hosp, Clin Res Unit, Swansea, W Glam, Wales
[3] London Sch Hyg & Trop Med, London WC1, England
[4] Darlington Mem Hosp, Cty Durham & Darlington Fdn Trust, Darlington, Durham, England
[5] Swansea Univ, Coll Human & Hlth Sci, Swansea Ctr Hlth Econ, Swansea, W Glam, Wales
[6] Singleton Hosp, Swansea SA2 8QA, W Glam, Wales
[7] Inst Med Diagnost GmbH, Bioscientia Lab Ingelheim, Ingelheim, Germany
关键词
SACCHAROMYCES-BOULARDII; COST-EFFECTIVENESS; PROBIOTIC FORMULA; ECONOMIC BURDEN; RISK-FACTORS; DISEASE; INFECTION; METAANALYSIS; EPIDEMIOLOGY; HEALTH;
D O I
暂无
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
引用
收藏
页码:1 / +
页数:134
相关论文
共 96 条
[1]  
Abubakar I, 2007, HEALTH TECHNOL ASSES, V11, P1
[2]  
Al-Eidan FA, 2000, J CLIN PHARM THER, V25, P101
[3]  
[Anonymous], 2012, British National Formulary
[4]  
[Anonymous], GUID METH TECHN APPR
[5]  
[Anonymous], INT C HARM TECHN REQ
[6]   Effect of Antibiotic Treatment on the Intestinal Metabolome [J].
Antunes, L. Caetano M. ;
Han, Jun ;
Ferreira, Rosana B. R. ;
Lolic, Petra ;
Borchers, Christoph H. ;
Finlay, B. Brett .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (04) :1494-1503
[7]   Enterotypes of the human gut microbiome [J].
Arumugam, Manimozhiyan ;
Raes, Jeroen ;
Pelletier, Eric ;
Le Paslier, Denis ;
Yamada, Takuji ;
Mende, Daniel R. ;
Fernandes, Gabriel R. ;
Tap, Julien ;
Bruls, Thomas ;
Batto, Jean-Michel ;
Bertalan, Marcelo ;
Borruel, Natalia ;
Casellas, Francesc ;
Fernandez, Leyden ;
Gautier, Laurent ;
Hansen, Torben ;
Hattori, Masahira ;
Hayashi, Tetsuya ;
Kleerebezem, Michiel ;
Kurokawa, Ken ;
Leclerc, Marion ;
Levenez, Florence ;
Manichanh, Chaysavanh ;
Nielsen, H. Bjorn ;
Nielsen, Trine ;
Pons, Nicolas ;
Poulain, Julie ;
Qin, Junjie ;
Sicheritz-Ponten, Thomas ;
Tims, Sebastian ;
Torrents, David ;
Ugarte, Edgardo ;
Zoetendal, Erwin G. ;
Wang, Jun ;
Guarner, Francisco ;
Pedersen, Oluf ;
de Vos, Willem M. ;
Brunak, Soren ;
Dore, Joel ;
Weissenbach, Jean ;
Ehrlich, S. Dusko ;
Bork, Peer .
NATURE, 2011, 473 (7346) :174-180
[8]   Probiotics for prevention of antibiotic-associated diarrhea and Clostridium difficile-associated disease in hospitalized adults-A meta-analysis [J].
Avadhani, Amita ;
Miley, Helen .
JOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS, 2011, 23 (06) :269-274
[9]   Clostridium difficile: Epidemiology, Pathogenesis, Management, and Prevention of a Recalcitrant Healthcare-Associated Pathogen [J].
Badger, Victor O. ;
Ledeboer, Nate A. ;
Graham, Mary Beth ;
Edmiston, Charles E., Jr. .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2012, 36 (06) :645-662
[10]   Antibiotic-associated diarrhea [J].
Bartlett, JG .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (05) :334-339