Periodontal pockets: A potential reservoir for SARS-CoV-2?

被引：80

作者：

Badran, Zahi ^{[1
,2
]}

Gaudin, Alexis ^{[3
]}

Struillou, Xavier ^{[1
]}

Amador, Gilles ^{[4
]}

Soueidan, Assem ^{[1
]}

机构：

[1] Univ Nantes, CHU Nantes, Dept Periodontol Rmes U1229, UIC 11,Fac Dent Surg, Nantes, France

[2] McGill Univ, Fac Dent, Montreal, PQ, Canada

[3] Univ Nantes, CHU Nantes, Dept Endodont Rmes U1229, UIC 11,Fac Dent Surg, Nantes, France

[4] Univ Nantes, CHU Nantes, Dept Dent Publ Hlth UPRES EA 3826, UIC 11,Fac Dent Surg, Nantes, France

来源：

MEDICAL HYPOTHESES | 2020年 / 143卷

关键词：

VIRUSES; INFECTION; CELLS; HEALTHY; DISEASE;

D O I：

10.1016/j.mehy.2020.109907

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Periodontal pockets are the major clinical manifestation of Periodontitis, a chronic inflammatory oral disease affecting the teeth-supporting tissues and has high prevalence in the adult population. Periodontal pockets are ideal environments for subgingival bacterial biofilms, that interact with the supragingival oral cavity, mucosal tissues of the pocket and a peripheral circulatory system. Periodontal pockets have been found to harbor viral species such as the Herpes simplex viruses' family. Recently, the SARS-CoV-2 has gained major interest of the scientific/medical community as it caused a global pandemic (Covid-19) and paralyzed the globe with high figures of infected people worldwide. This virus behavior is still partially understood, and by analyzing some of its features we hypothesized that periodontal pocket could be a favorable anatomical niche for the virus and thus acting as a reservoir for SARS-CoV-2.

引用

页数：3

共 40 条

[11] Salivary levels of Epstein-Barr virus DNA correlate with subgingival levels, not severity of periodontitis [J].