Surface Coated Eu(OH)3 Nanorods: A Facile Synthesis, Characterization, MR Relaxivities and In Vitro Cytotoxicity

被引：14

作者：

Kattel, Krishna ^{[1
]}

Park, Ja Young ^{[1
]}

Xu, Wenlong ^{[1
]}

Bony, Badrul Alam ^{[1
]}

Heo, Woo Cheol ^{[1
]}

Tegafaw, Tirusew ^{[1
]}

Kim, Cho Rong ^{[1
]}

Ahmad, Md Wasi ^{[1
]}

Jin, Seonguk ^{[2
]}

Baeck, Jong Su ^{[2
]}

Chang, Yongmin ^{[2
]}

Kim, Tae Jeong ^{[3
]}

Bae, Ji Eun ^{[4
]}

Chae, Kwon Seok ^{[5
]}

Jeong, Ji Yun ^{[6
]}

Lee, Gang Ho ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Taegu 702701, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Mol Med & Med & Biol Engn, Taegu 702701, South Korea

[3] Kyungpook Natl Univ, Coll Engn, Dept Appl Chem, Taegu 702701, South Korea

[4] Kyungpook Natl Univ, Dept Nanosci & Nanotechnol, Taegu 702701, South Korea

[5] Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Taegu 702701, South Korea

[6] Kyungpook Natl Univ, Sch Med, Dept Endocrinol & Metab, Taegu 702701, South Korea

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2013年 / 13卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

Eu(OH)(3) Nanorod; Fluorescent Properties; Cytotoxicity; Water Proton Relaxivities; GADOLINIUM OXIDE NANOPARTICLES; CONTRAST AGENTS; VIVO; EU2O3; HYDROXIDE; SCALE; EU;

D O I：

10.1166/jnn.2013.8081

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The water-soluble and biocompatible D-glucuronic acid coated Eu(OH)(3) nanorods (average thickness x average length = 9.0 x 118.3 nm) have been prepared in one-pot synthesis. The D-glucuronic acid coated Eu(OH)(3) nanorods showed a strong fluorescence at similar to 600 nm with a narrow emission band width. A cytotoxicity test by using DU145 cells showed that D-glucuronic acid coated Eu(OH)(3) nanorods are not toxic up to 100 mu M, making them a promising candidate for biomedical applications such as fluorescent imaging. The minimum Eu concentration needed for a conventional confocal imaging was estimated to be similar to 0.1 mM. Therefore, D-glucuronic acid coated Eu(OH)(3) nanorods can be applied to fluorescent imaging. However, a very tiny magnetization of similar to 1.2 emu/g at room temperature and at an applied field of 5 tesla was observed. As a result, very small r(1) and r(2) water proton relaxivities were estimated, implying that surface coated Eu(OH)(3) nanorods are not sufficient for MRI contrast agents.

引用

页码：7214 / 7219

页数：6

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