Analgesic and antidiarrheal properties of Ocimum selloi essential oil in mice

被引：26

作者：

Franca, Carolina S. ^{[1
]}

Menezes, Fabia S. ^{[1
]}

Costa, Larissa C. B. ^{[3
]}

Niculau, Edenilson S. ^{[2
]}

Alves, Pericles B. ^{[2
]}

Pinto, Jose E. B. ^{[3
]}

Marcal, Rosilene M. ^{[1
]}

机构：

[1] Univ Fed Sergipe, Physiol Dept DFS, BR-49100000 Sao Cristovao, Sergipe, Brazil

[2] Univ Fed Sergipe, Dept Chem, BR-49100000 Sao Cristovao, Sergipe, Brazil

[3] Univ Fed Lavras, BR-37200000 Lavras, MG, Brazil

来源：

FITOTERAPIA | 2008年 / 79卷 / 7-8期

关键词：

Ocimum selloi; Methyl chavicol; Antidiarrheal; Analgesic;

D O I：

10.1016/j.fitote.2008.06.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ocimum selloi essential oil (2, 20, and 200 mg/kg; p.o.) reduced, in a dose-dependent way, the abdominal contraction induced by acetic acid (0.6%; i.p.) and the diarrhea episodes induced by castor oil in mice. At the higher dose (200 mg/kg. p.o.), the essential oil significantly, reduced intestinal transit (P<0.05) in the charcoal meat test. The main component detected in O. selloi essential oil was methyl chavicol (98%; GC and GC/MS).These effects seems to support the use of O. selloi against diarrhea, intestinal spasm and visceral pain. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：569 / 573

页数：5

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