Remarkable anti-breast cancer activity of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines

被引：34

作者：

Jadhav, Jagannath ^{[1
]}

Juvekar, Aarti ^{[2
]}

Kurane, Rajanikant ^{[1
]}

Khanapure, Sharanabasappa ^{[1
]}

Salunkhe, Rajashri ^{[1
]}

Rashinkar, Gajanan ^{[1
]}

机构：

[1] Shivaji Univ, Dept Chem, Kolhapur 416004, MS, India

[2] Tata Mem Hosp, Adv Ctr Treatment Res & Educ Canc, Navi Mumbai 410210, MS, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 65卷

关键词：

Ferrrocene; 1,4-Dihydropyrimidines; Ferrocenyl chalcones; Amidines; Anti breast cancer activity; ANTICANCER ACTIVITY; ASYMMETRIC CATALYSIS; DERIVATIVES; LIGANDS; DIHYDROPYRIMIDINES; ELECTROCHEMISTRY; ANTAGONISTS; INHIBITION; DENDRIMERS; CHALCONES;

D O I：

10.1016/j.ejmech.2013.04.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of H-1 NMR, C-13 NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI(50) value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：232 / 239

页数：8

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