Hereditary diffuse gastric cancer and lost cell polarity: a short path to cancer

被引：6

作者：

Humar, Bostjan ^{[1
]}

Guilford, Parry ^{[1
]}

机构：

[1] Univ Otago, Canc Genet Lab, Dept Biochem, Dunedin, New Zealand

来源：

FUTURE ONCOLOGY | 2008年 / 4卷 / 02期

关键词：

chemoprevention; DNA methylation; E-cadherin; epigenetic therapy; HDAC inhibitors; hereditary diffuse gastric cancer; hypoxia; polarity; stem cells;

D O I：

10.2217/14796694.4.2.229

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mechanisms that underlie the initiation of human cancer are poorly understood. Here, we describe the development of hereditary diffuse gastric cancer and argue that it arises from the disruption of the regenerative processes that are inherent to all epithelial tissues. This model supports the cancer stem cell hypothesis, in which tumors contain a subpopulation of cells with the key stem cell characteristics of capacity for self renewal, differentiation and limitless replication. We argue that epigenetic modifications induced by common environmental and physiological pressures are able to initiate this disruption. The carcinogenic effects of these modifications are potentially reversible through the use of epigenetic therapies such as DNA demethylating agents and histone deacetylation inhibitors.

引用

页码：229 / 239

页数：11

共 86 条

[11] Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells [J].