Cohort Profile: TwinsUK and Healthy Ageing Twin Study

被引：180

作者：

Moayyeri, Alireza ^{[1
]}

Hammond, Christopher J. ^{[1
]}

Valdes, Ana M. ^{[1
]}

Spector, Timothy D. ^{[1
]}

机构：

[1] Kings Coll London, St Thomas Hosp, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2013年 / 42卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会; 英国惠康基金; 欧盟第七框架计划;

关键词：

GENOME-WIDE ASSOCIATION; GENETIC-LOCI; COMMON VARIANTS; METAANALYSIS; AGE; OSTEOARTHRITIS; PHENOTYPES; SAMPLE; HEART;

D O I：

10.1093/ije/dyr207

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The UK's largest registry of adult twins, or TwinsUK Registry, started in 1992 and encompasses about 12 000 volunteer twins from all over the United Kingdom. More than 70% of the registered twins have filled at least one detailed health questionnaire and about half of them undergone a baseline comprehensive assessment and two follow-up clinical evaluations. The most recent follow-up visit, known as Healthy Ageing Twin Study (HATS), involved 3125 female twins aged > 40 years with at least one previous clinical assessment to enable inspection of longitudinal changes in ageing traits and their genetic and environmental components. The study benefits from several state-of-the-art OMICs studies including genome-wide association, next-generation genome and transcriptome sequencing, and epigenetic and metabolomic profiles. This makes our cohort as one of the most deeply phenotyped and genotyped in the world. Several collaborative projects in the field of epidemiology of complex disorders are ongoing in our cohort and interested researchers are encouraged to get in contact for future collaborations.

引用

页码：76 / 85

页数：10

共 47 条

[1] Hundreds of variants clustered in genomic loci and biological pathways affect human height [J].

Allen, Hana Lango ;

Estrada, Karol ;

Lettre, Guillaume ;

Berndt, Sonja I. ;

Weedon, Michael N. ;

Rivadeneira, Fernando ;

Willer, Cristen J. ;

Jackson, Anne U. ;

Vedantam, Sailaja ;

Raychaudhuri, Soumya ;

Ferreira, Teresa ;

Wood, Andrew R. ;

Weyant, Robert J. ;

Segre, Ayellet V. ;

Speliotes, Elizabeth K. ;

Wheeler, Eleanor ;

Soranzo, Nicole ;

Park, Ju-Hyun ;

Yang, Jian ;

Gudbjartsson, Daniel ;

Heard-Costa, Nancy L. ;

Randall, Joshua C. ;

Qi, Lu ;

Smith, Albert Vernon ;

Maegi, Reedik ;

Pastinen, Tomi ;

Liang, Liming ;

Heid, Iris M. ;

Luan, Jian'an ;

Thorleifsson, Gudmar ;

Winkler, Thomas W. ;

Goddard, Michael E. ;

Lo, Ken Sin ;

Palmer, Cameron ;

Workalemahu, Tsegaselassie ;

Aulchenko, Yurii S. ;

Johansson, Asa ;

Zillikens, M. Carola ;

Feitosa, Mary F. ;

Esko, Tonu ;

Johnson, Toby ;

Ketkar, Shamika ;

Kraft, Peter ;

Mangino, Massimo ;

Prokopenko, Inga ;

Absher, Devin ;

Albrecht, Eva ;

Ernst, Florian ;

Glazer, Nicole L. ;

Hayward, Caroline .

NATURE, 2010, 467 (7317) :832-838

[2] Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs [J].

Andrew, T ;

Aviv, A ;

Falchi, M ;

Surdulescu, GL ;

Gardner, JP ;

Lu, XB ;

Kimura, M ;

Kato, BS ;

Valdes, AM ;

Spector, TD .

AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 78 (03) :480-486

[3]

Andrew T, 2001, Twin Res, V4, P464, DOI 10.1375/1369052012803

[4] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts [J].

Aulchenko, Yurii S. ;

Ripatti, Samuli ;

Lindqvist, Ida ;

Boomsma, Dorret ;

Heid, Iris M. ;

Pramstaller, Peter P. ;

Penninx, Brenda W. J. H. ;

Janssens, A. Cecile J. W. ;

Wilson, James F. ;

Spector, Tim ;

Martin, Nicholas G. ;

Pedersen, Nancy L. ;

Kyvik, Kirsten Ohm ;

Kaprio, Jaakko ;

Hofman, Albert ;

Freimer, Nelson B. ;

Jarvelin, Marjo-Riitta ;

Gyllensten, Ulf ;

Campbell, Harry ;

Rudan, Igor ;

Johansson, Asa ;

Marroni, Fabio ;

Hayward, Caroline ;

Vitart, Veronique ;

Jonasson, Inger ;

Pattaro, Cristian ;

Wright, Alan ;

Hastie, Nick ;

Pichler, Irene ;

Hicks, Andrew A. ;

Falchi, Mario ;

Willemsen, Gonneke ;

Hottenga, Jouke-Jan ;

de Geus, Eco J. C. ;

Montgomery, Grant W. ;

Whitfield, John ;

Magnusson, Patrik ;

Saharinen, Juha ;

Perola, Markus ;

Silander, Kaisa ;

Isaacs, Aaron ;

Sijbrands, Eric J. G. ;

Uitterlinden, Andre G. ;

Witteman, Jacqueline C. M. ;

Oostra, Ben A. ;

Elliott, Paul ;

Ruokonen, Aimo ;

Sabatti, Chiara ;

Gieger, Christian ;

Meitinger, Thomas .

NATURE GENETICS, 2009, 41 (01) :47-55

[5] Common variants near TERC are associated with mean telomere length [J].

Codd, Veryan ;

Mangino, Massimo ;

van der Harst, Pim ;

Braund, Peter S. ;

Kaiser, Michael ;

Beveridge, Alan J. ;

Rafelt, Suzanne ;

Moore, Jasbir ;

Nelson, Chris ;

Soranzo, Nicole ;

Zhai, Guangju ;

Valdes, Ana M. ;

Blackburn, Hannah ;

Leach, Irene Mateo ;

de Boer, Rudolf A. ;

Goodall, Alison H. ;

Ouwehand, Willem ;

van Veldhuisen, Dirk J. ;

van Gilst, Wiek H. ;

Navis, Gerjan ;

Burton, Paul R. ;

Tobin, Martin D. ;

Hall, Alistair S. ;

Thompson, John R. ;

Spector, Tim ;

Samani, Nilesh J. .

NATURE GENETICS, 2010, 42 (03) :197-199

[6] Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels [J].

Dehghan, Abbas ;

Dupuis, Josee ;

Barbalic, Maja ;

Bis, Joshua C. ;

Eiriksdottir, Gudny ;

Lu, Chen ;

Pellikka, Niina ;

Wallaschofski, Henri ;

Kettunen, Johannes ;

Henneman, Peter ;

Baumert, Jens ;

Strachan, David P. ;

Fuchsberger, Christian ;

Vitart, Veronique ;

Wilson, James F. ;

Pare, Guillaume ;

Naitza, Silvia ;

Rudock, Megan E. ;

Surakka, Ida ;

de Geus, Eco J. C. ;

Alizadeh, Behrooz Z. ;

Guralnik, Jack ;

Shuldiner, Alan ;

Tanaka, Toshiko ;

Zee, Robert Y. L. ;

Schnabel, Renate B. ;

Nambi, Vijay ;

Kavousi, Maryam ;

Ripatti, Samuli ;

Nauck, Matthias ;

Smith, Nicholas L. ;

Smith, Albert V. ;

Sundvall, Jouko ;

Scheet, Paul ;

Liu, Yongmei ;

Ruokonen, Aimo ;

Rose, Lynda M. ;

Larson, Martin G. ;

Hoogeveen, Ron C. ;

Freimer, Nelson B. ;

Teumer, Alexander ;

Tracy, Russell P. ;

Launer, Lenore J. ;

Buring, Julie E. ;

Yamamoto, Jennifer F. ;

Folsom, Aaron R. ;

Sijbrands, Eric J. G. ;

Pankow, James ;

Elliott, Paul ;

Keaney, John F. .

CIRCULATION, 2011, 123 (07) :731-U151

[7] IRF4 Variants Have Age-Specific Effects on Nevus Count and Predispose to Melanoma [J].

Duffy, David L. ;

Iles, Mark M. ;

Glass, Dan ;

Zhu, Gu ;

Barrett, Jennifer H. ;

Hoiom, Veronica ;

Zhao, Zhen Z. ;

Sturm, Richard A. ;

Soranzo, Nicole ;

Hammond, Chris ;

Kvaskoff, Marina ;

Whiteman, David C. ;

Mangino, Massimo ;

Hansson, Johan ;

Newton-Bishop, Julia A. ;

Bataille, Veronique ;

Hayward, Nicholas K. ;

Martin, Nicholas G. ;

Bishop, D. Timothy ;

Spector, Timothy D. ;

Montgomery, Grant W. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 87 (01) :6-16

[8] Genetic influences on variation in female orgasmic function: a twin study [J].

Dunn, KM ;

Cherkas, LF ;

Spector, TD .

BIOLOGY LETTERS, 2005, 1 (03) :260-263

[9] New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk [J].

Dupuis, Josee ;

Langenberg, Claudia ;

Prokopenko, Inga ;

Saxena, Richa ;

Soranzo, Nicole ;

Jackson, Anne U. ;

Wheeler, Eleanor ;

Glazer, Nicole L. ;

Bouatia-Naji, Nabila ;

Gloyn, Anna L. ;

Lindgren, Cecilia M. ;

Magi, Reedik ;

Morris, Andrew P. ;

Randall, Joshua ;

Johnson, Toby ;

Elliott, Paul ;

Rybin, Denis ;

Thorleifsson, Gudmar ;

Steinthorsdottir, Valgerdur ;

Henneman, Peter ;

Grallert, Harald ;

Dehghan, Abbas ;

Hottenga, Jouke Jan ;

Franklin, Christopher S. ;

Navarro, Pau ;

Song, Kijoung ;

Goel, Anuj ;

Perry, John R. B. ;

Egan, Josephine M. ;

Lajunen, Taina ;

Grarup, Niels ;

Sparso, Thomas ;

Doney, Alex ;

Voight, Benjamin F. ;

Stringham, Heather M. ;

Li, Man ;

Kanoni, Stavroula ;

Shrader, Peter ;

Cavalcanti-Proenca, Christine ;

Kumari, Meena ;

Qi, Lu ;

Timpson, Nicholas J. ;

Gieger, Christian ;

Zabena, Carina ;

Rocheleau, Ghislain ;

Ingelsson, Erik ;

An, Ping ;

O'Connell, Jeffrey ;

Luan, Jian'an ;

Elliott, Amanda .

NATURE GENETICS, 2010, 42 (02) :105-U32

[10] Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies [J].

Elks, Cathy E. ;

Perry, John R. B. ;

Sulem, Patrick ;

Chasman, Daniel I. ;

Franceschini, Nora ;

He, Chunyan ;

Lunetta, Kathryn L. ;

Visser, Jenny A. ;

Byrne, Enda M. ;

Cousminer, Diana L. ;

Gudbjartsson, Daniel F. ;

Esko, Tonu ;

Feenstra, Bjarke ;

Hottenga, Jouke-Jan ;

Koller, Daniel L. ;

Kutalik, Zoltan ;

Lin, Peng ;

Mangino, Massimo ;

Marongiu, Mara ;

McArdle, Patrick F. ;

Smith, Albert V. ;

Stolk, Lisette ;

Van Wingerden, Sophie H. ;

Zhao, Jing Hua ;

Albrecht, Eva ;

Corre, Tanguy ;

Ingelsson, Erik ;

Hayward, Caroline ;

Magnusson, Patrik K. E. ;

Smith, Erin N. ;

Ulivi, Shelia ;

Warrington, Nicole M. ;

Zgaga, Lina ;

Alavere, Helen ;

Amin, Najaf ;

Aspelund, Thor ;

Bandinelli, Stefania ;

Barroso, Ines ;

Berenson, Gerald S. ;

Bergmann, Sven ;

Blackburn, Hannah ;

Boerwinkle, Eric ;

Buring, Julie E. ;

Busonero, Fabio ;

Campbell, Harry ;

Chanock, Stephen J. ;

Chen, Wei ;

Cornelis, Marilyn C. ;

Couper, David ;

Coviello, Andrea D. .

NATURE GENETICS, 2010, 42 (12) :1077-U73

← 1 2 3 4 5 →

共 47 条

[1] Hundreds of variants clustered in genomic loci and biological pathways affect human height [J].

Allen, Hana Lango ;

Estrada, Karol ;

Lettre, Guillaume ;

Berndt, Sonja I. ;

Weedon, Michael N. ;

Rivadeneira, Fernando ;

Willer, Cristen J. ;

Jackson, Anne U. ;

Vedantam, Sailaja ;

Raychaudhuri, Soumya ;

Ferreira, Teresa ;

Wood, Andrew R. ;

Weyant, Robert J. ;

Segre, Ayellet V. ;

Speliotes, Elizabeth K. ;

Wheeler, Eleanor ;

Soranzo, Nicole ;

Park, Ju-Hyun ;

Yang, Jian ;

Gudbjartsson, Daniel ;

Heard-Costa, Nancy L. ;

Randall, Joshua C. ;

Qi, Lu ;

Smith, Albert Vernon ;

Maegi, Reedik ;

Pastinen, Tomi ;

Liang, Liming ;

Heid, Iris M. ;

Luan, Jian'an ;

Thorleifsson, Gudmar ;

Winkler, Thomas W. ;

Goddard, Michael E. ;

Lo, Ken Sin ;

Palmer, Cameron ;

Workalemahu, Tsegaselassie ;

Aulchenko, Yurii S. ;

Johansson, Asa ;

Zillikens, M. Carola ;

Feitosa, Mary F. ;

Esko, Tonu ;

Johnson, Toby ;

Ketkar, Shamika ;

Kraft, Peter ;

Mangino, Massimo ;

Prokopenko, Inga ;

Absher, Devin ;

Albrecht, Eva ;

Ernst, Florian ;

Glazer, Nicole L. ;

Hayward, Caroline .

NATURE, 2010, 467 (7317) :832-838

[2] Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs [J].

Andrew, T ;

Aviv, A ;

Falchi, M ;

Surdulescu, GL ;

Gardner, JP ;

Lu, XB ;

Kimura, M ;

Kato, BS ;

Valdes, AM ;

Spector, TD .

AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 78 (03) :480-486

[3]

Andrew T, 2001, Twin Res, V4, P464, DOI 10.1375/1369052012803

[4] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts [J].

Aulchenko, Yurii S. ;

Ripatti, Samuli ;

Lindqvist, Ida ;

Boomsma, Dorret ;

Heid, Iris M. ;

Pramstaller, Peter P. ;

Penninx, Brenda W. J. H. ;

Janssens, A. Cecile J. W. ;

Wilson, James F. ;

Spector, Tim ;

Martin, Nicholas G. ;

Pedersen, Nancy L. ;

Kyvik, Kirsten Ohm ;

Kaprio, Jaakko ;

Hofman, Albert ;

Freimer, Nelson B. ;

Jarvelin, Marjo-Riitta ;

Gyllensten, Ulf ;

Campbell, Harry ;

Rudan, Igor ;

Johansson, Asa ;

Marroni, Fabio ;

Hayward, Caroline ;

Vitart, Veronique ;

Jonasson, Inger ;

Pattaro, Cristian ;

Wright, Alan ;

Hastie, Nick ;

Pichler, Irene ;

Hicks, Andrew A. ;

Falchi, Mario ;

Willemsen, Gonneke ;

Hottenga, Jouke-Jan ;

de Geus, Eco J. C. ;

Montgomery, Grant W. ;

Whitfield, John ;

Magnusson, Patrik ;

Saharinen, Juha ;

Perola, Markus ;

Silander, Kaisa ;

Isaacs, Aaron ;

Sijbrands, Eric J. G. ;

Uitterlinden, Andre G. ;

Witteman, Jacqueline C. M. ;

Oostra, Ben A. ;

Elliott, Paul ;

Ruokonen, Aimo ;

Sabatti, Chiara ;

Gieger, Christian ;

Meitinger, Thomas .

NATURE GENETICS, 2009, 41 (01) :47-55

[5] Common variants near TERC are associated with mean telomere length [J].

Codd, Veryan ;

Mangino, Massimo ;

van der Harst, Pim ;

Braund, Peter S. ;

Kaiser, Michael ;

Beveridge, Alan J. ;

Rafelt, Suzanne ;

Moore, Jasbir ;

Nelson, Chris ;

Soranzo, Nicole ;

Zhai, Guangju ;

Valdes, Ana M. ;

Blackburn, Hannah ;

Leach, Irene Mateo ;

de Boer, Rudolf A. ;

Goodall, Alison H. ;

Ouwehand, Willem ;

van Veldhuisen, Dirk J. ;

van Gilst, Wiek H. ;

Navis, Gerjan ;

Burton, Paul R. ;

Tobin, Martin D. ;

Hall, Alistair S. ;

Thompson, John R. ;

Spector, Tim ;

Samani, Nilesh J. .

NATURE GENETICS, 2010, 42 (03) :197-199

[6] Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels [J].

Dehghan, Abbas ;

Dupuis, Josee ;

Barbalic, Maja ;

Bis, Joshua C. ;

Eiriksdottir, Gudny ;

Lu, Chen ;

Pellikka, Niina ;

Wallaschofski, Henri ;

Kettunen, Johannes ;

Henneman, Peter ;

Baumert, Jens ;

Strachan, David P. ;

Fuchsberger, Christian ;

Vitart, Veronique ;

Wilson, James F. ;

Pare, Guillaume ;

Naitza, Silvia ;

Rudock, Megan E. ;

Surakka, Ida ;

de Geus, Eco J. C. ;

Alizadeh, Behrooz Z. ;

Guralnik, Jack ;

Shuldiner, Alan ;

Tanaka, Toshiko ;

Zee, Robert Y. L. ;

Schnabel, Renate B. ;

Nambi, Vijay ;

Kavousi, Maryam ;

Ripatti, Samuli ;

Nauck, Matthias ;

Smith, Nicholas L. ;

Smith, Albert V. ;

Sundvall, Jouko ;

Scheet, Paul ;

Liu, Yongmei ;

Ruokonen, Aimo ;

Rose, Lynda M. ;

Larson, Martin G. ;

Hoogeveen, Ron C. ;

Freimer, Nelson B. ;

Teumer, Alexander ;

Tracy, Russell P. ;

Launer, Lenore J. ;

Buring, Julie E. ;

Yamamoto, Jennifer F. ;

Folsom, Aaron R. ;

Sijbrands, Eric J. G. ;

Pankow, James ;

Elliott, Paul ;

Keaney, John F. .

CIRCULATION, 2011, 123 (07) :731-U151

[7] IRF4 Variants Have Age-Specific Effects on Nevus Count and Predispose to Melanoma [J].

Duffy, David L. ;

Iles, Mark M. ;

Glass, Dan ;

Zhu, Gu ;

Barrett, Jennifer H. ;

Hoiom, Veronica ;

Zhao, Zhen Z. ;

Sturm, Richard A. ;

Soranzo, Nicole ;

Hammond, Chris ;

Kvaskoff, Marina ;

Whiteman, David C. ;

Mangino, Massimo ;

Hansson, Johan ;

Newton-Bishop, Julia A. ;

Bataille, Veronique ;

Hayward, Nicholas K. ;

Martin, Nicholas G. ;

Bishop, D. Timothy ;

Spector, Timothy D. ;

Montgomery, Grant W. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 87 (01) :6-16

[8] Genetic influences on variation in female orgasmic function: a twin study [J].

Dunn, KM ;

Cherkas, LF ;

Spector, TD .

BIOLOGY LETTERS, 2005, 1 (03) :260-263

[9] New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk [J].

Dupuis, Josee ;

Langenberg, Claudia ;

Prokopenko, Inga ;

Saxena, Richa ;

Soranzo, Nicole ;

Jackson, Anne U. ;

Wheeler, Eleanor ;

Glazer, Nicole L. ;

Bouatia-Naji, Nabila ;

Gloyn, Anna L. ;

Lindgren, Cecilia M. ;

Magi, Reedik ;

Morris, Andrew P. ;

Randall, Joshua ;

Johnson, Toby ;

Elliott, Paul ;

Rybin, Denis ;

Thorleifsson, Gudmar ;

Steinthorsdottir, Valgerdur ;

Henneman, Peter ;

Grallert, Harald ;

Dehghan, Abbas ;

Hottenga, Jouke Jan ;

Franklin, Christopher S. ;

Navarro, Pau ;

Song, Kijoung ;

Goel, Anuj ;

Perry, John R. B. ;

Egan, Josephine M. ;

Lajunen, Taina ;

Grarup, Niels ;

Sparso, Thomas ;

Doney, Alex ;

Voight, Benjamin F. ;

Stringham, Heather M. ;

Li, Man ;

Kanoni, Stavroula ;

Shrader, Peter ;

Cavalcanti-Proenca, Christine ;

Kumari, Meena ;

Qi, Lu ;

Timpson, Nicholas J. ;

Gieger, Christian ;

Zabena, Carina ;

Rocheleau, Ghislain ;

Ingelsson, Erik ;

An, Ping ;

O'Connell, Jeffrey ;

Luan, Jian'an ;

Elliott, Amanda .

NATURE GENETICS, 2010, 42 (02) :105-U32

[10] Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies [J].

Elks, Cathy E. ;

Perry, John R. B. ;

Sulem, Patrick ;

Chasman, Daniel I. ;

Franceschini, Nora ;

He, Chunyan ;

Lunetta, Kathryn L. ;

Visser, Jenny A. ;

Byrne, Enda M. ;

Cousminer, Diana L. ;

Gudbjartsson, Daniel F. ;

Esko, Tonu ;

Feenstra, Bjarke ;

Hottenga, Jouke-Jan ;

Koller, Daniel L. ;

Kutalik, Zoltan ;

Lin, Peng ;

Mangino, Massimo ;

Marongiu, Mara ;

McArdle, Patrick F. ;

Smith, Albert V. ;

Stolk, Lisette ;

Van Wingerden, Sophie H. ;

Zhao, Jing Hua ;

Albrecht, Eva ;

Corre, Tanguy ;

Ingelsson, Erik ;

Hayward, Caroline ;

Magnusson, Patrik K. E. ;

Smith, Erin N. ;

Ulivi, Shelia ;

Warrington, Nicole M. ;

Zgaga, Lina ;

Alavere, Helen ;

Amin, Najaf ;

Aspelund, Thor ;

Bandinelli, Stefania ;

Barroso, Ines ;

Berenson, Gerald S. ;

Bergmann, Sven ;

Blackburn, Hannah ;

Boerwinkle, Eric ;

Buring, Julie E. ;

Busonero, Fabio ;

Campbell, Harry ;

Chanock, Stephen J. ;

Chen, Wei ;

Cornelis, Marilyn C. ;

Couper, David ;

Coviello, Andrea D. .

NATURE GENETICS, 2010, 42 (12) :1077-U73

← 1 2 3 4 5 →