Regulatory roles of circRNAs in adipogenesis and lipid metabolism: emerging insights into lipid-related diseases

被引：31

作者：

Chen, Chen ^{[1
]}

Zhang, Xing ^{[1
]}

Deng, Yuan ^{[1
]}

Cui, Qingming ^{[1
]}

Zhu, Ji ^{[1
]}

Ren, Huibo ^{[1
]}

Liu, Yingying ^{[1
]}

Hu, Xionggui ^{[1
]}

Zuo, Jianbo ^{[1
]}

Peng, Yinglin ^{[1
,2
]}

机构：

[1] Hunan Inst Anim & Vet Sci, Changsha 410131, Peoples R China

[2] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China

来源：

FEBS JOURNAL | 2021年 / 288卷 / 12期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

adipogenesis; characteristics; circRNAs; clinical; lipid metabolism; lipid-related diseases; CIRCULAR RNAS; HEPATOCELLULAR-CARCINOMA; TRANSCRIPTIONAL CONTROL; NONCODING RNAS; MESSENGER-RNAS; LIVER-DISEASE; STEM-CELLS; WEB TOOL; EXPRESSION; ACID;

D O I：

10.1111/febs.15525

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Disorder of lipid metabolism has become an urgent health problem that brings about a variety of metabolic syndromes, including hepatic steatosis, adipose tissue dysfunction, diabetes and obesity. Circular RNAs (circRNAs), a class of emerging RNA molecules with unique structure and extensive effects, have been verified to participate in various biological programs through distinct mechanisms, especially in lipid-related processes. In this review, the biogenesis, characteristics, and functional mechanisms of circRNAs are discussed. Furthermore, the methods for circRNA identification and expression profiles of circRNAs associated with adipogenesis and lipid metabolism are described. Additionally, we emphasize the regulatory roles of circRNAs in adipogenesis, lipid metabolism, and lipid-related diseases. Finally, the diagnostic and therapeutic potential of circRNAs is highlighted, showing potential for the clinical application of circRNAs in the treatment of lipid-related diseases in the near future.

引用

页码：3663 / 3682

页数：20

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