Immune correlates of protection from HIV and AIDS - more answers but yet more questions

被引:39
作者
Heeney, JL
Beverley, P
McMichael, A
Shearer, G
Strominger, J
Wahren, B
Weber, J
Gotch, F
机构
[1] Biomed Primate Res Ctr, Dept Virol, NL-2288 GJ Rijswijk, Netherlands
[2] Edward Jenner Inst, Newbury RG20 7NN, Berks, England
[3] John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England
[4] NCI, Dept Expt Immunol Branch, NIH, Bethesda, MD 20817 USA
[5] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[6] Karolinska Inst, Dept Virol, S-10521 Stockholm, Sweden
[7] Univ London Imperial Coll Sci Technol & Med, Jefferis Trust Labs, Dept Genitourinary Med & Communicable Dis, London W2 1NY, England
[8] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Dept Immunol, London SW10 9NH, England
来源
IMMUNOLOGY TODAY | 1999年 / 20卷 / 06期
关键词
D O I
10.1016/S0167-5699(98)01437-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Ar an international symposium*, specific clinical and preclinical settings were examined in order to increase our understanding of immunity to HIV. This data might help the design of more effective vaccine strategies for protection from HIV ou the treatment of AIDS.
引用
收藏
页码:247 / 251
页数:5
相关论文
共 34 条
[11]   Protection from pathogenic SIV challenge using multigenic DNA vaccines [J].
Haigwood, NL ;
Pierce, CC ;
Robertson, MN ;
Watson, AJ ;
Montefiori, DC ;
Rabin, M ;
Lynch, JB ;
Kuller, L ;
Thompson, J ;
Morton, WR ;
Benveniste, RE ;
Hu, SL ;
Greenberg, P ;
Mossman, SP .
IMMUNOLOGY LETTERS, 1999, 66 (1-3) :183-188
[12]   Immune strategies utilized by lentivirus infected chimpanzees to resist progression to AIDS [J].
Heeney, J ;
Bogers, W ;
Buijs, L ;
Dubbes, R ;
tenHaaft, P ;
Koornstra, W ;
Niphuis, H ;
Nara, P ;
Teeuwsen, V .
IMMUNOLOGY LETTERS, 1996, 51 (1-2) :45-52
[13]   AIDS - A DISEASE OF IMPAIRED TH-CELL RENEWAL [J].
HEENEY, JL .
IMMUNOLOGY TODAY, 1995, 16 (11) :515-520
[14]   β-Chemokines and neutralizing antibody titers correlate with sterilizing immunity generated in HIV-1 vaccinated macaques [J].
Heeney, JL ;
Teeuwsen, VJP ;
van Gils, M ;
Bogers, WMJM ;
Morghen, CD ;
Radaelli, A ;
Barnett, S ;
Morein, B ;
Åkerblom, L ;
Wang, YF ;
Lehner, T ;
Davis, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (18) :10803-10808
[15]   Induction of specific T-cell responses in HIV infection [J].
Leandersson, AC ;
Bratt, G ;
Hinkula, J ;
Gilljam, G ;
Cochaux, P ;
Samson, M ;
Sandström, E ;
Wahren, B .
AIDS, 1998, 12 (02) :157-166
[16]   Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques [J].
Lehner, T ;
Wang, YF ;
Cranage, M ;
Bergmeier, LA ;
Mitchell, E ;
Tao, L ;
Hall, G ;
Dennis, M ;
Cook, N ;
Brookes, R ;
Klavinskis, L ;
Doyle, C ;
Ward, R .
NATURE MEDICINE, 1996, 2 (07) :767-775
[17]   Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease [J].
Li, TS ;
Tubiana, R ;
Katlama, C ;
Calvez, V ;
Ait Mohand, H ;
Autran, B .
LANCET, 1998, 351 (9117) :1682-1686
[18]   CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency [J].
Liu, Z ;
Cumberland, WG ;
Hultin, LE ;
Kaplan, AH ;
Detels, R ;
Giorgi, JV .
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 1998, 18 (04) :332-340
[19]   Suppression of human immunodeficiency virus type 1 replication by a soluble factor produced by CD8+ lymphocytes from HIV-2-infected baboons [J].
Locher, CP ;
Blackbourn, DJ ;
Levy, JA .
IMMUNOLOGY LETTERS, 1999, 66 (1-3) :151-157
[20]   CD4(+) T-CELLS ARE REQUIRED TO SUSTAIN CD8(+) CYTOTOXIC T-CELL RESPONSES DURING CHRONIC VIRAL-INFECTION [J].
MATLOUBIAN, M ;
CONCEPCION, RJ ;
AHMED, R .
JOURNAL OF VIROLOGY, 1994, 68 (12) :8056-8063