Diabetes mellitus type 2: Exploratory data analysis based on clinical reading

被引:4
作者
Nedyalkova, Miroslava [1 ]
Madurga, Sergio [2 ,3 ]
Ballabio, Davide [4 ]
Robeva, Ralitsa [5 ]
Romanova, Julia [1 ]
Kichev, Ilia [1 ]
Elenkova, Atanaska [5 ]
Simeonov, Vasil [6 ]
机构
[1] Univ Sofia St Kl Ohridski, Fac Chem & Pharm, Dept Inorgan Chem, 1 Ave J Bourchier, Sofia 1164, Bulgaria
[2] Univ Barcelona UB, Dept Phys Chem, C Marti i Franques 1, Barcelona 08028, Spain
[3] Univ Barcelona UB, Res Inst Theoret & Computat Chem IQTCUB, C Marti i Franques 1, Barcelona 08028, Spain
[4] Univ Milano Bicocca, Dept Earth & Environm Sci, Chemometr & QSAR Res Grp, Piazza Sci 1, I-20126 Milan, Italy
[5] Med Univ Sofia, Dept Endocrinol, Fac Med, Sofia 1431, Ushate Acad Iv, Bulgaria
[6] Univ Sofia St Kl Ohridski, Fac Chem & Pharm, Dept Analyt Chem, 1 Ave J Bourchier, Sofia 1164, Bulgaria
来源
OPEN CHEMISTRY | 2020年 / 18卷 / 01期
关键词
diabetes mellitus type 2; exploratory data analysis; classification; PCA; CA; PLS-DA; PARTIAL LEAST-SQUARES; INSULIN-RESISTANCE; CLASSIFICATION; PREVALENCE; COSTS;
D O I
10.1515/chem-2020-0086
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Diabetes mellitus type 2 (DMT2) is a severe and complex health problem. It is the most common type of diabetes. DMT2 is a chronic metabolic disorder that affects the way your body metabolizes sugar. With DMT2, your body either resists the effects of insulin or does not produce sufficient insulin to continue normal glucose levels. DMT2 is a disease that requires a multifactorial approach of controlling that includes lifestyle change and pharmacotherapy. Less than ideal management increases the risk of developing complications and comorbidities such as cardiovascular disease and numerous social and economic penalties. That is why the studies dedicated to the pathophysiological mechanisms and the treatment of DMT2 are extremely numerous and diverse. In this study, exploratory data analysis approaches are applied for the treatment of clinical and anthropometric readings of patients with DMT2. Since multivariate statistics is a well-known method for classification, modeling and interpretation of large collections of data, the major aim of the present study was to reveal latent relations between the objects of the investigation (group of patients and control group) and the variables describing the objects (clinical and anthropometric parameters). In the proposed method by the application of hierarchical cluster analysis and principal component analysis it is possible to identify reduced number of parameters which appear to be the most significant discriminant parameters to distinguish between four patterns of patients with DMT2. However, there is still lack of multivariate statistical studies using DMT2 data sets to assess different aspects of the problem like optimal rapid monitoring of the patients or specific separation of patients into patterns of similarity related to their health status which could be of help in preparation of data bases for DMT2 patients. The outcome from the study could be of custom for the selection of significant tests for rapid monitoring of patients and more detailed approach to the health status of DMT2 patients.
引用
收藏
页码:1041 / 1053
页数:13
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