Prognostic value of serum PIIINP, MMP1 and TIMP1 levels in hypertensive patients: a community-based prospective cohort study

被引：16
作者：
Agrinier, Nelly [1 ,2 ,3 ]
Thilly, Nathalie [1 ,2 ,3 ]
Boivin, Jean-Marc [4 ,5 ]
Dousset, Brigitte [6 ]
Alla, Francois [1 ,2 ,3 ]
Zannad, Faiez [4 ,5 ]
机构：
[1] INSERM, CIC EC, CIE6, F-54000 Nancy, France
[2] CHU Nancy, Epidemiol & Evaluat Clin, F-54000 Nancy, France
[3] Univ Lorraine, CIC EC, CIE 6, F-54000 Nancy, France
[4] Univ Lorraine, INSERM, Dept Cardiol, CIC9501, F-54500 Vandoeuvre Les Nancy, France
[5] Univ Lorraine, CHU, Hypertens & Heart Failure Unit, CHU Nancy,U961, F-54500 Vandoeuvre Les Nancy, France
[6] CHU Nancy, Lab Biochim Specialisee, Nancy, France
来源：
FUNDAMENTAL & CLINICAL PHARMACOLOGY | 2013年 / 27卷 / 05期
关键词：
biological markers; extracellular matrix; hypertension; hypertrophy; left ventricular; prognosis; EXTRACELLULAR-MATRIX TURNOVER; LEFT-VENTRICULAR MASS; ACUTE MYOCARDIAL-INFARCTION; CARDIOVASCULAR RISK-FACTORS; PROCOLLAGEN TYPE-I; HEART-FAILURE; DIASTOLIC DYSFUNCTION; CIRCULATING MARKERS; TISSUE INHIBITOR; FIBROSIS;
D O I：
10.1111/j.1472-8206.2012.01053.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of this study was to examine the prognostic value of serum ECM biomarkers in hypertensive patients with no history of cardiovascular events. In a community-based cohort study of 125 hypertensive patients free of cardiovascular events, we collected clinical data and blood samples to assess serum levels of amino-terminal propeptide of type III procollagen (PIIINP), matrix metalloproteinase type 1(MMP1) and tissue inhibitor of MMPs type 1(TIMP1). Left ventricular hypertrophy (LVH) was assessed using the ECG Cornell product. Patients were followed up for death or cardiovascular hospitalisation. We used Cox regression models to assess the prognostic value of ECM biomarkers. The sample included 60.8% women; the mean (+/- SD) age was 62.9 (+/- 11.4) years. Patients were followed up for a median of 5.5years, during which 23 events (five deaths) occurred. PIIINP (3.2 +/- 1.0 vs. 2.6 +/- 0.8g/L, P=0.001) and TIMP1 (886 +/- 168 vs. 751 +/- 202g/L, P<0.001) levels were higher in the presence of LVH than with no LVH. Basal MMP1 serum levels were significantly associated with CV events (MMP1: HR, 1.06; 95%CI [1.02-1.09]). Adjusting for confounders did not modify this result. Cardiac fibrosis, as assessed with serum ECM biomarkers, might develop early in hypertensive patients and is predictive of cardiovascular events or death.
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收藏
页码：572 / 580
页数：9
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