A highly selective and sensitive "turn-on" fluorescent probe for rapid recognition and detection of Cu2+ in aqueous solution and in living cells

被引：21

作者：

Jiang, Nan ^{[1
]}

Gong, Xue ^{[1
]}

Zhong, Tianyuan ^{[1
]}

Zheng, Yue ^{[1
]}

Wang, Guang ^{[1
]}

机构：

[1] Northeast Normal Univ, Key Lab Nanobiosensing & Nanobioanal Univ Jilin P, Fac Chem, Changchun 130024, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2020年 / 1219卷

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Fluorescence probe; Copper ion; Density functional theory; Test paper; Cell imaging; COLORIMETRIC CHEMOSENSOR; ALZHEIMERS-DISEASE; COPPER DEFICIENCY; IONS DETECTION; CU(II) IONS; FE3+; PYRENE; SENSOR; RHODAMINE; PRION;

D O I：

10.1016/j.molstruc.2020.128573

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A 5-formyl-2-hydroxybenzoicacid-based fluorescence probe (L) for Cu2+ ions was designed and synthesized. L in CH3CN:H2O (1:9, v/v) solution displayed highly selective and sensitive fluorescence 'off-on' response over all the other competitive metal ions including Fe2+, Fe3+, Mn2+, Ba2+, Pb2+, Co2+, Cr3+, Cd2+, Na+, Zn2+, Hg2+, Ag+, Ca2+, Al3+, Mg2+, K+, Ni2+ and Y3+. The fluorescence intensity of L presented good linear relationship to the Cu2+ concentration and with the lower detection limits of 2.19 x 10(-7) M for Cu2+ ion. Job's plot, mass spectra, Benesi-Hildebrand plot and DFT calculation confirmed that fluorescence increased was caused by the formation of 1:2 complex between L and copper ion. The recovery tests demonstrated that L could accurately detect the existence of Cu2+ ions in water samples. In addition, L can recognize Cu2+ ion in living cells via the fluorescence confocal images and in water samples via test papers mode. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：8

共 45 条

[1] Metals in Alzheimer's and Parkinson's diseases [J].