Functional parameters indicative of mild cognitive impairment: a systematic review using instrumented kinematic assessment

被引：12

作者：

Jose Fuentes-Abolafio, Ivan ^{[1
,2
]}

Stubbs, Brendon ^{[3
,4
,5
]}

Miguel Perez-Belmonte, Luis ^{[6
,7
,8
]}

Rosa Bernal-Lopez, Maria ^{[6
,9
]}

Gomez-Huelgas, Ricardo ^{[6
,9
]}

Cuesta-Vargas, Antonio ^{[1
,2
,10
]}

机构：

[1] Univ Malaga, Biomed Res Inst Malaga IBIMA, Fac Hlth Sci, Clinimetr Grp FE 14,Dept Physiotherapy, Malaga, Spain

[2] Av Arquitecto Penalosa S-N Teatinos Campus Expans, Malaga 29071, Spain

[3] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London, England

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England

[5] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Posit Ageing Res Intitute PARI, Chelmsford, Essex, England

[6] Reg Univ Hosp Malaga, Inst Invest Biomed Malaga IBIMA, Internal Med Dept, Malaga, Spain

[7] Univ Malaga, Inst Invest Biomed Malaga IBIMA, Ctr Invest Med Sanitarias CIMES, Unidad Neurofisiol Cognit, Campus Excelencia Int CEI Andalucia Tech, Malaga, Spain

[8] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

[9] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain

[10] Queensland Univ Technol, Fac Hlth, Sch Clin Sci, Brisbane, Qld, Australia

来源：

BMC GERIATRICS | 2020年 / 20卷 / 01期

关键词：

Mild cognitive impairment; Functional objective parameters; Instrumented assessment; Kinematics; Gait; Balance; MINI-MENTAL-STATE; OLDER-ADULTS; GAIT SPEED; PHYSICAL-EXERCISE; WORKING GROUP; DEMENTIA; RISK; DECLINE; PEOPLE; VARIABILITY;

D O I：

10.1186/s12877-020-01678-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

BackgroundPatients with mild cognitive impairment (MCI) experience alterations of functional parameters, such as an impaired balance or gait. The current systematic review set out to investigate whether functional objective performance may predict a future risk of MCI; to compare functional objective parameters in patients with MCI and a control group; and to assess changes in these parameters after different physical activity interventions.MethodsElectronic databases, including PubMed, AMED, CINAHL, EMBASE, PEDro and Web of Science as well as grey literature databases, were searched from inception to February 2020. Cohort studies and Randomized Controlled Trials (RCTs) were included. The risk of bias of the included studies was assessed independently by reviewers using quality assessment checklists. The level of evidence per outcome was assessed using the GRADE criteria.ResultsSeventeen studies met inclusion criteria including patients with MCI. Results from RCTs suggested that gait speed, gait variability and balance may be improved by different physical activity interventions. Cohort studies showed that slower gait speed, above all, under Dual Task (DT) conditions, was the main impaired parameter in patients with MCI in comparison with a Control Gorup. Furthermore, cohort studies suggested that gait variability could predict an incident MCI. Although most of included cohort studies reported low risk of bias, RCTs showed an unclear risk of bias.ConclusionsStudies suggest that gait variability may predict an incident MCI. Moreover, different gait parameters, above all under DT conditions, could be impaired in patients with MCI. These parameters could be improved by some physical activity interventions. Although cohort studies reported low risk of bias, RCTs showed an unclear risk of bias and GRADE criteria showed a low level of evidence per outcome, so further studies are required to refute our findings.ProsperoCRD42019119180.

引用

页数：13