Is Interstitial Cells of Cajal-opathy Present in Gastroparesis?

被引：13
作者：
Bashashati, Mohammad [1 ]
McCallum, Richard W. [1 ]
机构：
[1] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, El Paso, TX USA
来源：
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | 2015年 / 21卷 / 04期
关键词：
Gastroparesis; Interstitial cells of Cajal; Physiopathology; NITRIC-OXIDE SYNTHASE; GASTRIC ANTRUM; OXIDATIVE STRESS; SCF/C-KIT; WILD-TYPE; DEFICIENCY; EXPRESSION; STOMACH; PREVALENCE; SYMPTOMS;
D O I：
10.5056/jnm15075
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Gastroparesis (GP), defined as delayed gastric emptying in the absence of any mechanical obstruction, is a challenging clinical condition, mainly because of limited treatment options. Studies in animal models of delayed gastric emptying as well as patients with gastroparesis revealed depletion or ultrastructural changes of interstitial cells of Cajal (ICC) in the gastric tissue, recently termed ICC-opathy. ICC are the pacemakers of the gastrointestinal tract and are involved in the transmission of the neuronal signaling to the smooth muscles. Therefore, lack of ICC could be one explanation of delayed gastric emptying in gastroparetic patients. How frequently ICC changes are observed in gastroparesis is not yet clear. In this review, the data on gastric ICC counts and morphology in animal models and patients with gastroparesis are discussed.
引用
收藏
页码：486 / 493
页数：8
相关论文
共 50 条
[1]   Percutaneous endoscopically assisted transenteric full-thickness gastric biopsy: initial experience in humans [J].
Andrews, Christopher N. ;
Mintchev, Paul ;
Neshev, Emil ;
Fraser, Hughie F. ;
Storr, Martin ;
Bathe, Oliver F. ;
Urbanski, Stefan J. .
GASTROINTESTINAL ENDOSCOPY, 2011, 73 (05) :949-954
[2]   Loss of Interstitial Cells of Cajal and Patterns of Gastric Dysrhythmia in Patients With Chronic Unexplained Nausea and Vomiting [J].
Angeli, Timothy R. ;
Cheng, Leo K. ;
Du, Peng ;
Wang, Tim Hsu-Han ;
Bernard, Cheryl E. ;
Vannucchi, Maria-Giuliana ;
Faussone-Pellegrini, Maria Simonetta ;
Lahr, Christopher ;
Vather, Ryash ;
Windsor, John A. ;
Farrugia, Gianrico ;
Abell, Thomas L. ;
O'Grady, Gregory .
GASTROENTEROLOGY, 2015, 149 (01) :56-+
[3]   MOTILITY Is 'ICC-opathy' present in gastroparesis-like syndrome? [J].
Bashashati, Mohammad ;
McCallum, Richard W. .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2015, 12 (07) :375-376
[4]   Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis [J].
Battaglia, Edda ;
Bassotti, Gabrio ;
Bellone, Graziella ;
Dughera, Luca ;
Serra, Anna Maria ;
Chiusa, Luigi ;
Repici, Alessandro ;
Mioli, Pierroberto ;
Emanuelli, Giorgio .
WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (38) :6172-6177
[5]   Immunohistochemical analysis of myenteric ganglia and interstitial cells of Cajal in ulcerative colitis [J].
Bernardini, Nunzia ;
Segnani, Cristina ;
Ippolito, Chiara ;
De Giorgio, Roberto ;
Colucci, Rocchina ;
Faussone-Pellegrini, Maria Simonetta ;
Chiarugi, Massimo ;
Campani, Daniela ;
Castagna, Maura ;
Mattii, Letizia ;
Blandizzi, Corrado ;
Dolfi, Amelio .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2012, 16 (02) :318-327
[6]   Epidemiology and Natural History of Gastroparesis [J].
Bharucha, Adil E. .
GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2015, 44 (01) :9-+
[7]   Impaired contractile responses and altered expression and phosphorylation of Ca2+ sensitization proteins in gastric antrum smooth muscles from ob/ob mice [J].
Bhetwal, Bhupal P. ;
An, Changlong ;
Baker, Salah A. ;
Lyon, Kristin L. ;
Perrino, Brian A. .
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2013, 34 (02) :137-149
[8]   Electroacupuncture at ST36 Ameliorates Gastric Emptying and Rescues Networks of Interstitial Cells of Cajal in the Stomach of Diabetic Rats [J].
Chen, Yan ;
Xu, Juan Juan ;
Liu, Shi ;
Hou, Xiao Hua .
PLOS ONE, 2013, 8 (12)
[9]   Electroacupuncture at ST36 Increases Contraction of the Gastric Antrum and Improves the SCF/c-kit Pathway in Diabetic Rats [J].
Chen, Yan ;
Xu, Juanjuan ;
Liu, Shi ;
Hou, Xiaohua .
AMERICAN JOURNAL OF CHINESE MEDICINE, 2013, 41 (06) :1233-1249
[10]   Heme Oxygenase-1 Protects Interstitial Cells of Cajal From Oxidative Stress and Reverses Diabetic Gastroparesis [J].
Choi, Kyoung Moo ;
Gibbons, Simon J. ;
Nguyen, Tien V. ;
Stoltz, Gary J. ;
Lurken, Matthew S. ;
Ordog, Tamas ;
Szurszewski, Joseph H. ;
Farrugia, Gianrico .
GASTROENTEROLOGY, 2008, 135 (06) :2055-2064
12345