Smoking and 2-month culture conversion during anti-tuberculosis treatment

被引：53

作者：

Maciel, E. L. ^{[1
,2
]}

Brioschi, A. P. ^{[1
,2
]}

Peres, R. L. ^{[1
]}

Guidoni, L. M. ^{[1
,2
]}

Ribeiro, F. K. ^{[1
]}

Hadad, D. J. ^{[1
]}

Vinhas, S. A. ^{[1
]}

Zandonade, E. ^{[2
]}

Palaci, M. ^{[1
]}

Dietze, R. ^{[1
]}

Johnson, J. L. ^{[3
]}

机构：

[1] Univ Fed Espirito Santo, Ctr Ciencias Saude, Nucleo Doencas Infecciosas, Vitoria, ES, Brazil

[2] Univ Fed Espirito Santo, Ctr Ciencias Saude, Programa Posgrad Saude Colet, Vitoria, ES, Brazil

[3] Case Western Reserve Univ, Dept Med, Div Infect Dis, TB Res Unit, Cleveland, OH 44106 USA

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2013年 / 17卷 / 02期

基金：

美国国家卫生研究院;

关键词：

pulmonary tuberculosis; smoking; culture conversion; SPUTUM SMEAR CONVERSION; PULMONARY TUBERCULOSIS; CIGARETTE-SMOKING; ADULTS;

D O I：

10.5588/ijtld.12.0426

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

OBJECTIVE: To investigate risk factors for delayed sputum culture conversion to negative during anti-tuberculosis treatment, with an emphasis on smoking. DESIGN: Nested case-control study of adults with non-cavitary, culture-confirmed pulmonary tuberculosis (TB) participating in an anti-tuberculosis treatment trial in Brazil. A case of delayed culture conversion was a patient who remained culture-positive after 2 months of treatment. Odds ratios with 95% confidence intervals were calculated. RESULTS: Fifty-three cases and 240 control patients were analyzed. Smokers had three-fold greater odds of remaining culture-positive after 2 months of treatment (P = 0.007) than non-smokers, while smokers and ex-smokers who smoked >20 cigarettes a day had two-fold greater odds of remaining culture-positive after 2 months of treatment (P = 0.045). CONCLUSION: Cigarette smoking adversely affects culture conversion during anti-tuberculosis treatment. Support for smoking cessation should be considered to improve outcomes in TB control programs.

引用

页码：225 / 228

页数：4

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