Smoking and 2-month culture conversion during anti-tuberculosis treatment

被引：52
作者：
Maciel, E. L. [1 ,2 ]
Brioschi, A. P. [1 ,2 ]
Peres, R. L. [1 ]
Guidoni, L. M. [1 ,2 ]
Ribeiro, F. K. [1 ]
Hadad, D. J. [1 ]
Vinhas, S. A. [1 ]
Zandonade, E. [2 ]
Palaci, M. [1 ]
Dietze, R. [1 ]
Johnson, J. L. [3 ]
机构：
[1] Univ Fed Espirito Santo, Ctr Ciencias Saude, Nucleo Doencas Infecciosas, Vitoria, ES, Brazil
[2] Univ Fed Espirito Santo, Ctr Ciencias Saude, Programa Posgrad Saude Colet, Vitoria, ES, Brazil
[3] Case Western Reserve Univ, Dept Med, Div Infect Dis, TB Res Unit, Cleveland, OH 44106 USA
来源：
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2013年 / 17卷 / 02期
基金：
美国国家卫生研究院;
关键词：
pulmonary tuberculosis; smoking; culture conversion; SPUTUM SMEAR CONVERSION; PULMONARY TUBERCULOSIS; CIGARETTE-SMOKING; ADULTS;
D O I：
10.5588/ijtld.12.0426
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
OBJECTIVE: To investigate risk factors for delayed sputum culture conversion to negative during anti-tuberculosis treatment, with an emphasis on smoking. DESIGN: Nested case-control study of adults with non-cavitary, culture-confirmed pulmonary tuberculosis (TB) participating in an anti-tuberculosis treatment trial in Brazil. A case of delayed culture conversion was a patient who remained culture-positive after 2 months of treatment. Odds ratios with 95% confidence intervals were calculated. RESULTS: Fifty-three cases and 240 control patients were analyzed. Smokers had three-fold greater odds of remaining culture-positive after 2 months of treatment (P = 0.007) than non-smokers, while smokers and ex-smokers who smoked >20 cigarettes a day had two-fold greater odds of remaining culture-positive after 2 months of treatment (P = 0.045). CONCLUSION: Cigarette smoking adversely affects culture conversion during anti-tuberculosis treatment. Support for smoking cessation should be considered to improve outcomes in TB control programs.
引用
收藏
页码：225 / 228
页数：4
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