Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis

被引：380

作者：

Cadwell, Ken ^{[1
,2
]}

机构：

[1] NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 11期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; CHRONIC GRANULOMATOUS-DISEASE; CELLS REQUIRE AUTOPHAGY; CD8(+) T-CELLS; NF-KAPPA-B; DENDRITIC CELLS; LUNG INFLAMMATION; GENE ATG16L1; I INTERFERON; ANTIGEN PRESENTATION;

D O I：

10.1038/nri.2016.100

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autophagy has broad functions in immunity, ranging from cell-autonomous defence to coordination of complex multicellular immune responses. The successful resolution of infection and avoidance of autoimmunity necessitates efficient and timely communication between autophagy and pathways that sense the immune environment. The recent literature indicates that a variety of immune mediators induce or repress autophagy. It is also becoming increasingly clear that immune signalling cascades are subject to regulation by autophagy, and that a return to homeostasis following a robust immune response is critically dependent on this pathway. Importantly, examples of non-canonical forms of autophagy in mediating immunity are pervasive. In this article, the progress in elucidating mechanisms of crosstalk between autophagy and inflammatory signalling cascades is reviewed. Improved mechanistic understanding of the autophagy machinery offers hope for treating infectious and inflammatory diseases.

引用

页码：661 / 675

页数：15

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