Solvation and solubility of globular proteins

被引:19
作者
Wang, HW [1 ]
BenNaim, A [1 ]
机构
[1] HEBREW UNIV JERUSALEM, DEPT PHYS CHEM, IL-91904 JERUSALEM, ISRAEL
关键词
D O I
10.1021/jp961591b
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The solvation Gibbs energy of a globular protein is expressed in terms of its various ingredients. Estimating each of these ingredients leads to an estimate of the overall solvation Gibbs energy of globular protein. As expected, the contribution of the sum of all the hydrophilic groups on the surface of the protein makes the solvation Gibbs energy of the protein less positive. However, this may not be enough to make the solvation Gibbs energy negative. We found, quite unexpectedly, that correlations between pairs and triplets of hydrophilic groups substantially decrease the solvation Gibbs energy of the protein. Therefore we conclude that pair and higher order correlations between hydrophilic groups on the surface of the protein has a significant contribution to the high solubility of globular proteins.
引用
收藏
页码:1077 / 1086
页数:10
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