Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome

被引：17

作者：

Vickaryous, N. ^{[1
]}

Polanco-Echeverry, G. ^{[1
]}

Morrow, S. ^{[1
]}

Suraweera, N. ^{[1
]}

Thomas, H. ^{[2
]}

Tomlinson, I. ^{[3
]}

Silver, A. ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Cell & Mol Sci, London E1 2AT, England

[2] St Marks Hosp, Family Canc Clin, Harrow HA1 3UJ, Middx, England

[3] Canc Res UK, London Res Inst, Mol & Populat Genet Lab, London WC2A 3PX, England

来源：

BRITISH JOURNAL OF CANCER | 2008年 / 99卷 / 10期

关键词：

hereditary non-polyposis colorectal cancer; microsatellite instability; smooth-muscle myosin;

D O I：

10.1038/sj.bjc.6604737

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MS1+).

引用

页码：1726 / 1728

页数：3

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