The role of danger signals and ectonucleotidases in acute graft-versus-host disease

被引:15
作者
Apostolova, Petya [1 ]
Zeiser, Robert [1 ]
机构
[1] Albert Ludwigs Univ, Dept Hematol Oncol & Stem Cell Transplantat, Univ Freiburg, Med Ctr, Freiburg, Germany
关键词
Allogeneic hematopoietic cell transplantation; Graft-versus-host disease; DAMP; ATP; Adenosine; Ectonucleotidase; Inflammasome; Uric acid; Heat shock protein; HMGB1; S100 protein family; REGULATORY T-CELLS; HUMAN DENDRITIC CELLS; MOBILITY GROUP BOX-1; HEAT-SHOCK PROTEINS; TOLL-LIKE; EXTRACELLULAR ATP; URIC-ACID; TRANSPLANTATION CONTROL; NLRP3; INFLAMMASOME; HEPARAN-SULFATE;
D O I
10.1016/j.humimm.2016.02.005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Allogeneic hematopoietic cell transplantation (allo-HCT) represents the only curative treatment approach for many patients with benign or malignant diseases of the hematopoietic system. However, post-transplant morbidity and mortality are significantly increased by the development of acute graft-versus-host disease (GvHD). While alloreactive T cells act as the main cellular mediator of the GvH reaction, recent evidence suggests a critical role of the innate immune system in the early stages of GvHD initiation. Danger-associated molecular patterns released from the intracellular space as well as from the extracellular matrix activate antigen-presenting cells and set pro-inflammatory pathways in motion. This review gives an overview, about danger signals representing therapeutic targets with a clinical perspective with a particular focus on extracellular nucleotides and ectonucleotidases. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:1037 / 1047
页数:11
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