Optimal Meropenem Concentrations To Treat Multidrug-Resistant Pseudomonas aeruginosa Septic Shock

被引：68

作者：

Taccone, Fabio Silvio ^{[1
]}

Cotton, Frederic ^{[2
]}

Roisin, Sandrine ^{[3
]}

Vincent, Jean-Louis ^{[1
]}

Jacobs, Frederique ^{[4
]}

机构：

[1] Univ Libre Bruxelles, Dept Intens Care, Brussels, Belgium

[2] Univ Libre Bruxelles, Dept Biol Clin, Hop Erasme, Brussels, Belgium

[3] Univ Libre Bruxelles, Dept Microbiol, Hop Erasme, Brussels, Belgium

[4] Univ Libre Bruxelles, Dept Infect Dis, Hop Erasme, Brussels, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期

关键词：

GRAM-NEGATIVE BACTERIA; CEFEPIME; INFUSION; ANTIBIOTICS; CEFTAZIDIME; INFECTIONS; EFFICACY; THERAPY;

D O I：

10.1128/AAC.06389-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A patient with septic shock due to extensively drug resistant (XDR) Pseudomonas aeruginosa was cured by optimizing the meropenem (MEM) regimen to obtain at least 40% of the time between two administrations in which drug levels were four times higher than the MIC of the pathogen. As the standard drug dose did not achieve these optimal concentrations, the MEM regimen was progressively increased up to 12 g/day (3 g every 6 h in a 3-h extended infusion), which eventually resulted in sepsis resolution. High MEM dosage may represent a valuable therapeutic option for infection due to multidrug-resistant (MDR) strains, and drug monitoring would allow rapid regimen adjustment in clinical practice.

引用

页码：2129 / 2131

页数：3

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