Lateral packing of mineral crystals in bone collagen fibrils

被引：61

作者：

Burger, Christian ^{[1
]}

Zhou, Hong-wen ^{[1
]}

Wang, Hao ^{[2
]}

Sics, Igors ^{[1
]}

Hsiao, Benjamin S. ^{[1
]}

Chu, Benjamin ^{[1
]}

Graham, Lila ^{[2
]}

Glimcher, Melvin J. ^{[2
]}

机构：

[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Dept Orthoped Surg, Boston, MA 02115 USA

来源：

BIOPHYSICAL JOURNAL | 2008年 / 95卷 / 04期

关键词：

D O I：

10.1529/biophysj.107.128355

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Combined small-angle x-ray scattering and transmission electron microscopy studies of intramuscular fish bone (shad and herring) indicate that the lateral packing of nanoscale calcium-phosphate crystals in collagen fibrils can be represented by irregular stacks of platelet-shaped crystals, intercalated with organic layers of collagen molecules. The scattering intensity distribution in this system can be described by a modified Zernike-Prins model, taking preferred orientation effects into account. Using the model, the diffuse fan-shaped small-angle x-ray scattering intensity pro. le, dominating the equatorial region of the scattering pattern, could be quantitatively analyzed as a function of the degree of mineralization. The mineral platelets were found to be very thin (1.5 nm similar to 2.0 nm), having a narrow thickness distribution. The thickness of the organic layers between adjacent mineral platelets within a stack is more broadly distributed with the average value varying from 6 nm to 10 nm, depending on the extent of mineralization. The two-dimensional analytical scheme also leads to quantitative information about the preferred orientation of mineral stacks and the average height of crystals along the crystallographic c axis.

引用

页码：1985 / 1992

页数：8

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